.data <- fileset.list("result/step1/matrix")
.mkdir("result/step3")
.features <- readLines(.data$row)
.hash <- .features[str_detect(.features, "Hash")]
.hash.hdr <- "result/step1/hash"
.hash.data <- fileset.list(.hash.hdr)
.hash.info <- read.hash(.hash.data)

1. MS vs. HC at the major cell type level

final.cell.type <-
     fread("Tab/step2_cell_type.txt.gz") %>%
     left_join(.hash.info) %>%
     na.omit()

a. Prepare data to just include cells annotated for their cell types and phenotypes

.mkdir("result/step3/deg/")
.deg.data <- fileset.list("result/step3/deg/hc_ms")
if.needed(.deg.data, {
    .deg.data <-
        rcpp_mmutil_copy_selected_columns(.data$mtx,
                                          .data$row,
                                          .data$col,
                                          unique(final.cell.type$tag),
                                          "result/step3/deg/hc_ms")
})

b. Gene Q/C to remove genes with too many zeros

nnz.cutoff <- 500
cv.cutoff <- .8
.scores <- rcpp_mmutil_compute_scores(.deg.data$mtx,
                                      .deg.data$row,
                                      .deg.data$col)

row.scores <- setDT(.scores$row) %>%
    rename(gene = name) %>%                      # 
    filter(!str_detect(`gene`,"[Hh]ashtag")) %>% # remove hashtag
    as.data.table() %>%
    parse.gene()
.genes.interest <- c("PRDM1", "SGK1", "LBH", "DDIT4","GIMAP7","ID3","ICAM2")
.lab.dt <- row.scores[hgnc_symbol %in% .genes.interest]

plt <-
    ggplot(row.scores, aes(log1p(nnz), log1p(cv))) +
    theme_classic() +
    stat_density_2d(geom = "raster",
                    aes(fill = after_stat(sqrt(density))),
                    show.legend=F,
                    contour=F) +
    scale_fill_viridis_c() +
    geom_vline(xintercept = log1p(nnz.cutoff), col=2, lty = 2) +
    geom_hline(yintercept = log1p(cv.cutoff), col=2, lty = 2) +
    stat_density2d(linewidth=.2, colour="white") +
        geom_point(data=.lab.dt, pch=19, col="white", stroke=0, size=2) +
        geom_text_repel(aes(label=hgnc_symbol), data=.lab.dt, size=4, min.segment.length = .01, segment.color="white", color="white") +
    scale_x_continuous("Number of Non zeros", labels = function(x) num.sci(round(10^x))) +
    scale_y_continuous("Coefficient of variation", labels = function(x) num.sci(10^x))

print(plt)

PDF

c. Show that some genes of interest are not necessarily well expressed

.genes.interest <- c("PRDM1", "SGK1", "LBH", "DDIT4")

.dt.show <- 
    row.scores[hgnc_symbol %in% .genes.interest] %>% 
    arrange(`nnz`) %>% 
    mutate(x = `nnz`, y = 5000 + 100 * (1:n())) %>%
    mutate(lab = hgnc_symbol %&% "\n(" %&% `nnz` %&% ")")

plt <-
    ggplot(row.scores, aes((`nnz`))) +
    theme_classic() + ggtitle("Gene-level statistics: histogram of number of non-zeros") +
    geom_histogram(fill="gray", linewidth=.1, color="gray20", bins=50) +
    ggrepel::geom_text_repel(aes(x, y, label=lab),
                             data=.dt.show,
                             size = 4, color = 2, vjust=0, hjust=0) +
    geom_vline(aes(xintercept = x), data = .dt.show, lty = 2, col = 2) +
    scale_y_log10("count") +
    scale_x_continuous("number of non-zero across " %&% num.int(.scores$max.col) %&% " cells",
                       breaks = c(unique(.dt.show$x), c(1, 5000, 15000, 20000)))
print(plt)

.file <- fig.dir %&% "/Fig_gene_scores_nnz.pdf"
.gg.save(filename = .file, plot = plt, width=8, height=3)

PDF

d. Compute DEG statistics while adjusting batch effects

qc.features <- row.scores[nnz > nnz.cutoff & cv > cv.cutoff]

.qc.hdr <- "result/step3/deg/qc_hc_ms"
.qc.data <- fileset.list(.qc.hdr)

if.needed(.qc.data, {
    .qc.data <-
        rcpp_mmutil_copy_selected_rows(.deg.data$mtx,
                                       .deg.data$row,
                                       .deg.data$col,
                                       qc.features$gene,
                                       .qc.hdr)
})
.file <- "result/step3/hc_ms.rds"
if.needed(.file,
{
    ## cell types
    .celltype <-
        final.cell.type %>%
        select(tag, celltype) %>%
        as.data.frame()
    ## cell -> individual
    .cell2indv <- final.cell.type %>%
        left_join(.hash.info) %>%
        select(tag, subject) %>%
        unique %>%
        as.data.frame()
    ## individual -> disease
    .indv2exp <- .cell2indv %>%
        select(subject) %>%
        mutate(disease = substr(`subject`, 1, 2)) %>%
        as.data.frame()

    .deg.stat <-
        make.cocoa(.qc.data, .celltype, .cell2indv, .indv2exp,
                   knn = 100, .rank = 15, .take.ln = TRUE,
                   impute.by.knn = TRUE, num.threads = 16)
    ## save for computed results
    saveRDS(.deg.stat, .file)
})
.deg.stat <- readRDS(.file)

.cts <- unique(final.cell.type$celltype)
.indvs <- unique(final.cell.type$subject)

.hc.ms.dt <-
    list(tot = sort.col(.deg.stat$sum, .cts, .indvs),
         cfa = sort.col(.deg.stat$resid.ln.mu, .cts, .indvs),
         cfa.sd = sort.col(.deg.stat$resid.ln.mu.sd, .cts, .indvs)) %>%
    combine.statistics() %>%
    na.omit() %>%
    as.data.table() %>%
    (function(x) {
        x[, c("sample", "celltype") := tstrsplit(as.character(Var2), split="_")];
        x[, disease := substr(`sample`, 1, 2)];
        x[, gene := as.character(Var1)];
        x
    }) %>%
    dplyr::select(-Var1, -Var2) %>%
    as.data.table()

hc.ms.deg <-
    summarize.deg(.hc.ms.dt, tot.cutoff = 5) %>%
    as.data.table() %>%
    parse.gene()
plt <-
    .gg.plot(hc.ms.deg, aes(pv, fill=`celltype`)) +
    geom_histogram(bins=100, linewidth=.1, color="black") +
    xlab("p-value") +
    scale_fill_brewer(palette = "Paired")

print(plt)

PDF

DOWNLOAD: DEG MS vs HC

e. Comparison with the bulk DEG results

read.bulk <- function(.file) {
    fread(.file) %>%
        rename(hgnc_symbol = gene_name) %>%
        rename(bulk.t = t, bulk.pv = P.Value, bulk.qv = adj.P.Val) %>%
        dplyr::select(hgnc_symbol, starts_with("bulk"))
}

.file <- "data/DEG/20180513/deg.ms.hc.treg.mem.exvivo.sex_covar.ruv.txt"
bulk.mTreg.dt <- read.bulk(.file)

.file <- "data/DEG/20180513/deg.ms.hc.teff.mem.exvivo.sex_covar.ruv.txt"
bulk.mTconv.dt <- read.bulk(.file)

Memory Treg genes

Correlation 0.42 with p-value = 1.01e-92

PDF

  • Here, we computed correlation between the bulk and scRNA-seq results after selecting on the DEGs marginally significant in the bulk analysis (\(|t| > 2\)).

  • Two numbers below the marked genes: first, we show p-value of the bulk analysis; second, we show Bonferroni-adjusted p-values of the scRNA-seq analysis.

Memory Tconv genes

.sc <- hc.ms.deg[celltype == "mTconv"]

.bulk <- bulk.mTconv.dt

.out <- plot.bulk.sc(.sc,
                     .bulk,
                     .key.genes = c("PRDM1","SGK1","LBH","CD6","JUNB","ID3"),
                     fwer.cutoff = .01,
                     qv.cutoff = .2,
                     n.top = 5)

Correlation 0.28 with p-value = 4.3e-60

PDF

  • Here, we computed correlation between the bulk and scRNA-seq results after selecting on the DEGs marginally significant in the bulk analysis (\(|t| > 2\)).

  • Two numbers below the marked genes: first, we show p-value of the bulk analysis; second, we show Bonferroni-adjusted p-values of the scRNA-seq analysis.

Found 414 unique genes strongly perturbed by MS with FWER 5%

  • Up-regulated: 211

  • Down-regulated: 298

  • Total pairs of genes and cell types: 34,415

count.deg <- function(.dt, fwer.cutoff = .01) {
    .dt[fwer < fwer.cutoff &
        sign(ADD) == sign(ADE) &
        sign(ADC) == sign(ADE),
        .(n = .N),
        by = .(celltype,
               direction = if_else(z > 0, "up", "down"))
        ] %>%
        mutate(direction = factor(direction, c("up", "down"))) %>%
        group_by(celltype) %>%
        arrange(desc(direction)) %>%
        mutate(nc = cumsum(n)) %>%
        ungroup
}
.df <- count.deg(hc.ms.deg)

plt <-
    .gg.plot(.df, aes(x = celltype, y = n, group = direction, fill = direction)) +
    theme(legend.position = c(1,1)) +
    theme(legend.justification = c(1,1)) +
    xlab("cell type") + ylab("# DEG") +
    geom_bar(stat="identity") +
    geom_text(aes(y=nc, label=n)) +
    scale_fill_manual(values = c("#ef8a62","#67a9cf"))

print(plt)

PDF

2. Show genes with FWER \(< 5 \times 10^{-2}\)

.bulk.genes <-
    rbind(bulk.mTreg.dt[bulk.qv < .2, .(hgnc_symbol)],
          bulk.mTconv.dt[bulk.qv < .2, .(hgnc_symbol)]) %>%
    unique() %>%
    unlist()

hc.ms.deg[, c("ensembl_gene_id", "hgnc_symbol") := tstrsplit(`gene`, split="_")]

.genes.show <-
    hc.ms.deg[fwer < 0.05 &
              hgnc_symbol %in% .bulk.genes &
              sign(ADD) == sign(ADE) &
              sign(ADC) == sign(ADE)] %>%
    select(gene) %>%
    unique %>%
    unlist %>%
    as.character
hc.ms.deg[, c("ensembl_gene_id", "hgnc_symbol") := tstrsplit(`gene`, split="_")]

.genes.show <-
    hc.ms.deg[fwer < .05 &
              sign(ADD) == sign(ADE) &
              sign(ADC) == sign(ADE)] %>%
    select(gene) %>%
    unique() %>%
    unlist() %>%
    as.character()
ensembl_gene_id hgnc_symbol z_mTconv z_mTreg z_nTconv z_nTreg pv_mTconv pv_mTreg pv_nTconv pv_nTreg fwer_mTconv fwer_mTreg fwer_nTconv fwer_nTreg .link
CD137 -8.58 -39.57 -10.23 -15.98 9.14e-18 0e+00 1.41e-24 1.75e-57 7.83e-14 0e+00 1.2e-20 1.5e-53 PDF
CD161 8.09 13.88 1.12 2.75 6.01e-16 8.58e-44 2.61e-01 5.87e-03 5.14e-12 7.36e-40 1e+00 1e+00 PDF
CD183 -9.03 20.86 -11.29 -4.07 1.74e-19 1.22e-96 1.45e-29 4.67e-05 1.49e-15 1.05e-92 1.24e-25 3.92e-01 PDF
CD184 4.59 7.95 6.28 5.11 4.45e-06 1.82e-15 3.48e-10 3.26e-07 3.74e-02 1.55e-11 2.97e-06 2.78e-03 PDF
CD19 2.17 28.87 -0.39 -5.55 3.03e-02 2.53e-183 6.99e-01 2.79e-08 1e+00 2.18e-179 1e+00 2.38e-04 PDF
CD196 36.5 -18.43 -4.46 9.04 1.07e-291 7.35e-76 8.11e-06 1.51e-19 9.19e-288 6.31e-72 6.85e-02 1.29e-15 PDF
CD197 1.48 7.32 7.5 0.89 1.4e-01 2.52e-13 6.16e-14 3.74e-01 1e+00 2.14e-09 5.26e-10 1e+00 PDF
CD20 -19.75 -14.36 -26.22 -21.85 8.63e-87 8.75e-47 1.58e-151 7.48e-106 7.42e-83 7.51e-43 1.36e-147 6.43e-102 PDF
CD226 9.04 60.15 10.7 5.89 1.51e-19 0e+00 1.04e-26 3.8e-09 1.3e-15 0e+00 8.88e-23 3.25e-05 PDF
CD25 -0.3 75.24 -21.26 11.88 7.62e-01 0e+00 2.84e-100 1.55e-32 1e+00 0e+00 2.44e-96 1.34e-28 PDF
CD27 -63.24 -109.66 -74.51 -117.27 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 PDF
CD278 30.48 67.84 26.38 7.98 5.31e-204 0e+00 2.35e-153 1.45e-15 4.57e-200 0e+00 2.02e-149 1.24e-11 PDF
CD279 11.18 11.84 0.22 -3.49 4.93e-29 2.5e-32 8.28e-01 4.75e-04 4.23e-25 2.14e-28 1e+00 1e+00 PDF
CD3 -19.26 -89.23 -39.89 -53.7 1.1e-82 0e+00 0e+00 0e+00 9.43e-79 0e+00 0e+00 0e+00 PDF
CD366 4.6 23.15 1.87 -1.62 4.29e-06 1.38e-118 6.12e-02 1.06e-01 3.61e-02 1.18e-114 1e+00 1e+00 PDF
CD45RA -81.69 -33.67 -80.72 -2.06 0e+00 1.5e-248 0e+00 3.98e-02 0e+00 1.29e-244 0e+00 1e+00 PDF
CD45RO -4.04 -17.12 6.23 8.33 5.32e-05 1.04e-65 4.66e-10 8.42e-17 4.43e-01 8.97e-62 3.97e-06 7.22e-13 PDF
CD58 2.82 17.8 1.46 0.57 4.83e-03 6.73e-71 1.44e-01 5.66e-01 1e+00 5.78e-67 1e+00 1e+00 PDF
CD8a 2.09 19.17 3.11 -6.17 3.7e-02 6.95e-82 1.86e-03 6.85e-10 1e+00 5.97e-78 1e+00 5.86e-06 PDF
ENSG00000002586 CD99 2.79 5.17 -0.69 4.85 5.26e-03 2.34e-07 4.92e-01 1.22e-06 1e+00 1.96e-03 1e+00 1.03e-02 PDF
ENSG00000003056 M6PR -1.54 -5.01 -4.3 -5.34 1.24e-01 5.49e-07 1.73e-05 9.43e-08 1e+00 4.6e-03 1.46e-01 8.03e-04 PDF
ENSG00000008517 IL32 9.92 16.74 7.07 9.29 3.24e-23 7.26e-63 1.49e-12 1.49e-20 2.78e-19 6.23e-59 1.28e-08 1.28e-16 PDF
ENSG00000008988 RPS20 -2.84 -9.02 -0.73 -4.78 4.45e-03 1.81e-19 4.67e-01 1.78e-06 1e+00 1.55e-15 1e+00 1.51e-02 PDF
ENSG00000009790 TRAF3IP3 -7.63 -9.81 -7.71 -8.98 2.31e-14 9.9e-23 1.22e-14 2.67e-19 1.98e-10 8.46e-19 1.04e-10 2.29e-15 PDF
ENSG00000009844 VTA1 -5.52 -4.86 -2.61 -0.38 3.46e-08 1.15e-06 9.01e-03 7.06e-01 2.94e-04 9.63e-03 1e+00 1e+00 PDF
ENSG00000011600 TYROBP -1.06 5.98 0.83 -0.43 2.91e-01 2.28e-09 4.05e-01 6.64e-01 1e+00 1.93e-05 1e+00 1e+00 PDF
ENSG00000013573 DDX11 -5.16 -2.51 -3.75 -2.23 2.5e-07 1.2e-02 1.77e-04 2.57e-02 2.12e-03 1e+00 1e+00 1e+00 PDF
ENSG00000019582 CD74 -2.04 3.47 -5.4 2.16 4.11e-02 5.28e-04 6.76e-08 3.09e-02 1e+00 1e+00 5.75e-04 1e+00 PDF
ENSG00000025708 TYMP 1.72 7.52 -0.4 -1.45 8.55e-02 5.4e-14 6.89e-01 1.48e-01 1e+00 4.59e-10 1e+00 1e+00 PDF
ENSG00000026025 VIM 27.17 18.97 2.98 7.67 1.6e-162 2.77e-80 2.92e-03 1.74e-14 1.38e-158 2.38e-76 1e+00 1.49e-10 PDF
ENSG00000026297 RNASET2 4.7 1.98 -0.22 0.91 2.61e-06 4.82e-02 8.29e-01 3.65e-01 2.2e-02 1e+00 1e+00 1e+00 PDF
ENSG00000026508 CD44 1.54 6.05 0.76 1.14 1.23e-01 1.43e-09 4.47e-01 2.55e-01 1e+00 1.21e-05 1e+00 1e+00 PDF
ENSG00000030582 GRN -0.82 5.17 1.52 -0.09 4.1e-01 2.38e-07 1.29e-01 9.29e-01 1e+00 2e-03 1e+00 1e+00 PDF
ENSG00000034510 TMSB10 12.74 19.37 11.15 2.29 3.65e-37 1.28e-83 7.08e-29 2.18e-02 3.14e-33 1.1e-79 6.07e-25 1e+00 PDF
ENSG00000036448 MYOM2 5.07 5.32 -4.14 0.59 4e-07 1.06e-07 3.4e-05 5.56e-01 3.38e-03 8.89e-04 2.86e-01 1e+00 PDF
ENSG00000038274 MAT2B -2.37 -5.89 -2.86 -2.74 1.79e-02 3.85e-09 4.18e-03 6.06e-03 1e+00 3.25e-05 1e+00 1e+00 PDF
ENSG00000041357 PSMA4 -5.1 -2.11 -1.74 -0.27 3.35e-07 3.5e-02 8.24e-02 7.83e-01 2.84e-03 1e+00 1e+00 1e+00 PDF
ENSG00000047410 TPR -3.67 -5.58 0.05 -4.46 2.44e-04 2.36e-08 9.6e-01 8.36e-06 1e+00 1.99e-04 1e+00 7.06e-02 PDF
ENSG00000048405 ZNF800 -1.07 -4.9 -2.66 -3.11 2.85e-01 9.61e-07 7.84e-03 1.9e-03 1e+00 8.03e-03 1e+00 1e+00 PDF
ENSG00000051108 HERPUD1 8.56 9.62 4.81 5.41 1.13e-17 6.74e-22 1.52e-06 6.2e-08 9.66e-14 5.75e-18 1.29e-02 5.28e-04 PDF
ENSG00000056558 TRAF1 0.81 -4.68 -1.11 -1.2 4.16e-01 2.9e-06 2.68e-01 2.3e-01 1e+00 2.41e-02 1e+00 1e+00 PDF
ENSG00000057657 PRDM1 5.71 7.1 2.31 2.1 1.1e-08 1.28e-12 2.1e-02 3.59e-02 9.38e-05 1.08e-08 1e+00 1e+00 PDF
ENSG00000059377 TBXAS1 0.17 4.99 1.04 1 8.64e-01 6.08e-07 2.98e-01 3.17e-01 1e+00 5.09e-03 1e+00 1e+00 PDF
ENSG00000059804 SLC2A3 0.65 4.14 -4.76 -5.69 5.16e-01 3.45e-05 1.91e-06 1.26e-08 1e+00 2.84e-01 1.62e-02 1.08e-04 PDF
ENSG00000064666 CNN2 1.86 5.05 1.54 0.04 6.35e-02 4.44e-07 1.24e-01 9.7e-01 1e+00 3.72e-03 1e+00 1e+00 PDF
ENSG00000064933 PMS1 -2.41 -4.89 -4.17 -4.5 1.61e-02 1e-06 3.09e-05 6.65e-06 1e+00 8.38e-03 2.61e-01 5.62e-02 PDF
ENSG00000065978 YBX1 6.82 -1.3 4.49 3.43 9.01e-12 1.93e-01 7.11e-06 6.05e-04 7.69e-08 1e+00 6.01e-02 1e+00 PDF
ENSG00000066379 ZNRD1 -3.41 -4.54 -4.96 -1.28 6.6e-04 5.66e-06 7.16e-07 1.99e-01 1e+00 4.7e-02 6.07e-03 1e+00 PDF
ENSG00000067082 KLF6 -4.9 -6.03 -2.09 2.42 9.5e-07 1.6e-09 3.62e-02 1.56e-02 8.02e-03 1.36e-05 1e+00 1e+00 PDF
ENSG00000069399 BCL3 5.24 7.84 0.37 1.31 1.59e-07 4.54e-15 7.1e-01 1.91e-01 1.35e-03 3.86e-11 1e+00 1e+00 PDF
ENSG00000069424 KCNAB2 -4.97 -1.93 -3.96 -0.53 6.76e-07 5.4e-02 7.37e-05 5.96e-01 5.71e-03 1e+00 6.18e-01 1e+00 PDF
ENSG00000069493 CLEC2D -6.42 -4.82 -5.8 -3.86 1.36e-10 1.46e-06 6.75e-09 1.11e-04 1.16e-06 1.22e-02 5.75e-05 9.31e-01 PDF
ENSG00000071073 MGAT4A 4.47 6.29 4 5.42 7.78e-06 3.24e-10 6.31e-05 6.06e-08 6.54e-02 2.74e-06 5.29e-01 5.17e-04 PDF
ENSG00000073578 SDHA -2.63 -4.76 -0.89 -1.53 8.64e-03 1.9e-06 3.75e-01 1.27e-01 1e+00 1.59e-02 1e+00 1e+00 PDF
ENSG00000075624 ACTB -2.22 -9.06 -8.5 -4.83 2.67e-02 1.35e-19 1.84e-17 1.34e-06 1e+00 1.15e-15 1.58e-13 1.13e-02 PDF
ENSG00000077420 APBB1IP -4.2 -5.21 -5.8 -3.78 2.68e-05 1.84e-07 6.71e-09 1.59e-04 2.24e-01 1.55e-03 5.72e-05 1e+00 PDF
ENSG00000078304 PPP2R5C -1.15 -2.38 -5.04 -2.67 2.49e-01 1.72e-02 4.65e-07 7.62e-03 1e+00 1e+00 3.95e-03 1e+00 PDF
ENSG00000080824 HSP90AA1 -1.74 -5.42 -4.98 0.9 8.25e-02 6.05e-08 6.27e-07 3.67e-01 1e+00 5.09e-04 5.32e-03 1e+00 PDF
ENSG00000081059 TCF7 -4.44 -9.21 0.71 -0.37 9.06e-06 3.21e-20 4.75e-01 7.14e-01 7.6e-02 2.74e-16 1e+00 1e+00 PDF
ENSG00000081237 PTPRC -3.76 -3.03 -3.25 -5.57 1.71e-04 2.45e-03 1.15e-03 2.56e-08 1e+00 1e+00 1e+00 2.19e-04 PDF
ENSG00000083223 TUT7 -4.72 -1.73 -1.01 -0.2 2.36e-06 8.43e-02 3.11e-01 8.4e-01 1.99e-02 1e+00 1e+00 1e+00 PDF
ENSG00000087074 PPP1R15A -4.94 5.77 0.18 -0.44 7.67e-07 7.7e-09 8.56e-01 6.58e-01 6.47e-03 6.49e-05 1e+00 1e+00 PDF
ENSG00000087086 FTL 8.92 18.24 12.08 6.07 4.87e-19 2.46e-74 1.34e-33 1.25e-09 4.17e-15 2.12e-70 1.15e-29 1.07e-05 PDF
ENSG00000088986 DYNLL1 -5.11 -5.89 -2.74 -3.62 3.19e-07 3.85e-09 6.06e-03 2.97e-04 2.7e-03 3.25e-05 1e+00 1e+00 PDF
ENSG00000089692 LAG3 2.17 7.43 -0.39 0 3.02e-02 1.07e-13 6.95e-01 1e+00 1e+00 9.1e-10 1e+00 1e+00 PDF
ENSG00000090104 RGS1 -5.02 4.69 -2.47 -4.99 5.07e-07 2.72e-06 1.35e-02 6.18e-07 4.29e-03 2.26e-02 1e+00 5.25e-03 PDF
ENSG00000091317 CMTM6 9.72 2.41 -1.59 -0.54 2.42e-22 1.59e-02 1.11e-01 5.9e-01 2.08e-18 1e+00 1e+00 1e+00 PDF
ENSG00000092820 EZR 2.1 3.98 1.21 4.83 3.58e-02 6.98e-05 2.26e-01 1.34e-06 1e+00 5.71e-01 1e+00 1.13e-02 PDF
ENSG00000099985 OSM 6.97 1.34 2.6 1.26 3.2e-12 1.81e-01 9.26e-03 2.09e-01 2.73e-08 1e+00 1e+00 1e+00 PDF
ENSG00000100097 LGALS1 12.57 5.86 2.04 2.08 2.99e-36 4.67e-09 4.1e-02 3.76e-02 2.56e-32 3.94e-05 1e+00 1e+00 PDF
ENSG00000100100 PIK3IP1 -0.59 -0.54 2.2 4.84 5.52e-01 5.91e-01 2.79e-02 1.32e-06 1e+00 1e+00 1e+00 1.12e-02 PDF
ENSG00000100129 EIF3L 1.58 -6.27 2.53 -1.37 1.15e-01 3.66e-10 1.13e-02 1.69e-01 1e+00 3.09e-06 1e+00 1e+00 PDF
ENSG00000100201 DDX17 -3.06 -4.84 -2.27 -3.55 2.19e-03 1.27e-06 2.32e-02 3.91e-04 1e+00 1.06e-02 1e+00 1e+00 PDF
ENSG00000100219 XBP1 4.64 3.87 12.26 5.51 3.5e-06 1.09e-04 1.43e-34 3.57e-08 2.95e-02 8.86e-01 1.23e-30 3.05e-04 PDF
ENSG00000100288 CHKB 0.07 3.58 4.62 1.28 9.41e-01 3.41e-04 3.88e-06 2e-01 1e+00 1e+00 3.28e-02 1e+00 PDF
ENSG00000100300 TSPO 7.68 5.86 3.29 2.05 1.57e-14 4.62e-09 1e-03 4.07e-02 1.34e-10 3.9e-05 1e+00 1e+00 PDF
ENSG00000100906 NFKBIA 21.3 6.07 8.9 16.98 1.21e-100 1.24e-09 5.81e-19 1.1e-64 1.04e-96 1.05e-05 4.97e-15 9.45e-61 PDF
ENSG00000101439 CST3 1.58 5.07 3.24 -2.48 1.13e-01 4.08e-07 1.21e-03 1.31e-02 1e+00 3.42e-03 1e+00 1e+00 PDF
ENSG00000101695 RNF125 2.87 2.51 1.71 6.83 4.12e-03 1.21e-02 8.66e-02 8.38e-12 1e+00 1e+00 1e+00 7.17e-08 PDF
ENSG00000102007 PLP2 7.21 6.83 0.93 3.74 5.66e-13 8.43e-12 3.51e-01 1.81e-04 4.83e-09 7.15e-08 1e+00 1e+00 PDF
ENSG00000102226 USP11 -4.57 -1.63 -1.69 -1.73 4.94e-06 1.04e-01 9.07e-02 8.36e-02 4.15e-02 1e+00 1e+00 1e+00 PDF
ENSG00000102245 CD40LG -4.87 -1.66 -4.35 -2.37 1.13e-06 9.78e-02 1.33e-05 1.76e-02 9.52e-03 1e+00 1.12e-01 1e+00 PDF
ENSG00000102760 RGCC -3.84 0 -5.38 -2.57 1.25e-04 9.99e-01 7.63e-08 1.01e-02 1e+00 1e+00 6.49e-04 1e+00 PDF
ENSG00000102879 CORO1A -4.95 -6.68 -2.16 -3.63 7.39e-07 2.42e-11 3.08e-02 2.79e-04 6.24e-03 2.06e-07 1e+00 1e+00 PDF
ENSG00000103064 SLC7A6 -4.65 -5.28 -2.11 -4.86 3.39e-06 1.32e-07 3.48e-02 1.16e-06 2.85e-02 1.1e-03 1e+00 9.8e-03 PDF
ENSG00000103121 CMC2 -1.13 -3.31 -2.56 -5.28 2.57e-01 9.42e-04 1.04e-02 1.3e-07 1e+00 1e+00 1e+00 1.1e-03 PDF
ENSG00000103202 NME4 1.14 1.71 2.41 5.03 2.52e-01 8.71e-02 1.61e-02 4.81e-07 1e+00 1e+00 1e+00 4.08e-03 PDF
ENSG00000103479 RBL2 0.28 -4.94 -0.01 0.1 7.8e-01 7.91e-07 9.91e-01 9.19e-01 1e+00 6.61e-03 1e+00 1e+00 PDF
ENSG00000103811 CTSH 7.21 4.14 1.43 -0.11 5.62e-13 3.47e-05 1.53e-01 9.16e-01 4.8e-09 2.85e-01 1e+00 1e+00 PDF
ENSG00000104964 AES 3.22 5.06 0.13 -1.34 1.28e-03 4.24e-07 8.97e-01 1.81e-01 1e+00 3.55e-03 1e+00 1e+00 PDF
ENSG00000105352 CEACAM4 -0.4 0.61 1.64 7.02 6.9e-01 5.43e-01 1e-01 2.29e-12 1e+00 1e+00 1e+00 1.96e-08 PDF
ENSG00000105655 ISYNA1 -1.53 -4.65 -1.3 -1.23 1.25e-01 3.33e-06 1.92e-01 2.2e-01 1e+00 2.77e-02 1e+00 1e+00 PDF
ENSG00000105835 NAMPT -1.52 4.89 -0.1 -0.69 1.29e-01 1.03e-06 9.17e-01 4.9e-01 1e+00 8.63e-03 1e+00 1e+00 PDF
ENSG00000106460 TMEM106B -2.22 -5.99 -1.34 -3.1 2.64e-02 2.13e-09 1.8e-01 1.94e-03 1e+00 1.8e-05 1e+00 1e+00 PDF
ENSG00000106560 GIMAP2 -5.88 -7.12 -5.38 -7.02 3.99e-09 1.06e-12 7.27e-08 2.23e-12 3.39e-05 8.99e-09 6.18e-04 1.91e-08 PDF
ENSG00000106605 BLVRA 0.64 5.3 -0.6 3.3 5.25e-01 1.15e-07 5.47e-01 9.77e-04 1e+00 9.7e-04 1e+00 1e+00 PDF
ENSG00000107281 NPDC1 4.61 -4 2.6 0.67 3.97e-06 6.44e-05 9.32e-03 5.05e-01 3.34e-02 5.27e-01 1e+00 1e+00 PDF
ENSG00000107738 VSIR 2.55 4.86 2.52 4 1.07e-02 1.16e-06 1.18e-02 6.21e-05 1e+00 9.65e-03 1e+00 5.21e-01 PDF
ENSG00000107968 MAP3K8 -1.5 3.86 -0.84 5.23 1.34e-01 1.13e-04 4e-01 1.66e-07 1e+00 9.21e-01 1e+00 1.41e-03 PDF
ENSG00000108518 PFN1 4.62 -0.29 -1.68 -0.57 3.81e-06 7.69e-01 9.26e-02 5.69e-01 3.2e-02 1e+00 1e+00 1e+00 PDF
ENSG00000108590 MED31 -3.51 -4.59 -1.45 -3.17 4.45e-04 4.54e-06 1.47e-01 1.54e-03 1e+00 3.77e-02 1e+00 1e+00 PDF
ENSG00000108622 ICAM2 -6.41 -10.36 -4.63 -5.33 1.5e-10 3.85e-25 3.6e-06 1.01e-07 1.28e-06 3.29e-21 3.04e-02 8.57e-04 PDF
ENSG00000109775 UFSP2 -1.66 -2.33 -4.71 -1.55 9.78e-02 1.98e-02 2.52e-06 1.21e-01 1e+00 1e+00 2.13e-02 1e+00 PDF
ENSG00000109971 HSPA8 3.36 -7.32 -2.75 -8.3 7.85e-04 2.46e-13 5.94e-03 1.01e-16 1e+00 2.09e-09 1e+00 8.66e-13 PDF
ENSG00000110172 CHORDC1 -0.43 -4.74 -0.49 -0.76 6.66e-01 2.13e-06 6.27e-01 4.5e-01 1e+00 1.78e-02 1e+00 1e+00 PDF
ENSG00000110848 CD69 -5.37 -3.01 -3.56 -5.04 7.81e-08 2.65e-03 3.68e-04 4.65e-07 6.63e-04 1e+00 1e+00 3.95e-03 PDF
ENSG00000111348 ARHGDIB -0.86 -1.44 -1.87 -4.67 3.88e-01 1.51e-01 6.15e-02 2.94e-06 1e+00 1e+00 1e+00 2.49e-02 PDF
ENSG00000111640 GAPDH 4.68 -8.26 -4.84 -2.48 2.89e-06 1.44e-16 1.31e-06 1.33e-02 2.44e-02 1.22e-12 1.11e-02 1e+00 PDF
ENSG00000111679 PTPN6 -5.01 -2.81 -4.68 -4.55 5.48e-07 4.97e-03 2.92e-06 5.45e-06 4.63e-03 1e+00 2.47e-02 4.61e-02 PDF
ENSG00000111796 KLRB1 7.04 9.21 0.71 6.62 1.89e-12 3.27e-20 4.76e-01 3.48e-11 1.61e-08 2.79e-16 1e+00 2.98e-07 PDF
ENSG00000112110 MRPL18 -5.26 -3.52 -3.51 -4.84 1.46e-07 4.25e-04 4.5e-04 1.31e-06 1.24e-03 1e+00 1e+00 1.11e-02 PDF
ENSG00000112486 CCR6 4.75 0.07 -0.16 0.96 2.02e-06 9.42e-01 8.71e-01 3.36e-01 1.71e-02 1e+00 1e+00 1e+00 PDF
ENSG00000112773 TENT5A 0.55 0.08 0.68 -4.73 5.84e-01 9.4e-01 4.98e-01 2.2e-06 1e+00 1e+00 1e+00 1.86e-02 PDF
ENSG00000113088 GZMK -14.32 -10.65 -7.77 -3.57 1.72e-46 1.7e-26 7.69e-15 3.64e-04 1.48e-42 1.45e-22 6.58e-11 1e+00 PDF
ENSG00000113593 PPWD1 -4.98 -3.5 -2.26 -2.52 6.2e-07 4.59e-04 2.41e-02 1.19e-02 5.24e-03 1e+00 1e+00 1e+00 PDF
ENSG00000113732 ATP6V0E1 -1.73 -1.39 -3.12 -5.18 8.32e-02 1.64e-01 1.79e-03 2.21e-07 1e+00 1e+00 1e+00 1.88e-03 PDF
ENSG00000113749 HRH2 -0.23 -4.69 -0.28 -2.58 8.22e-01 2.76e-06 7.76e-01 9.83e-03 1e+00 2.3e-02 1e+00 1e+00 PDF
ENSG00000114737 CISH -0.16 0.29 6.16 0.78 8.77e-01 7.7e-01 7.15e-10 4.34e-01 1e+00 1e+00 6.1e-06 1e+00 PDF
ENSG00000115306 SPTBN1 -4.18 -6.13 1.14 -0.25 2.86e-05 8.74e-10 2.55e-01 8e-01 2.39e-01 7.39e-06 1e+00 1e+00 PDF
ENSG00000115687 PASK 5.94 3.55 11.32 3.71 2.84e-09 3.88e-04 9.91e-30 2.09e-04 2.42e-05 1e+00 8.49e-26 1e+00 PDF
ENSG00000115758 ODC1 4.28 6.81 5.79 5.61 1.86e-05 9.97e-12 7.2e-09 1.97e-08 1.56e-01 8.46e-08 6.13e-05 1.69e-04 PDF
ENSG00000116350 SRSF4 -2.54 -4.99 -1.03 -1.24 1.11e-02 6.15e-07 3.01e-01 2.14e-01 1e+00 5.15e-03 1e+00 1e+00 PDF
ENSG00000116717 GADD45A 1.01 4.94 0.72 1.57 3.12e-01 7.9e-07 4.74e-01 1.16e-01 1e+00 6.61e-03 1e+00 1e+00 PDF
ENSG00000116741 RGS2 0.33 5.28 -1.95 2.12 7.38e-01 1.27e-07 5.12e-02 3.39e-02 1e+00 1.07e-03 1e+00 1e+00 PDF
ENSG00000116754 SRSF11 -2.63 -6.27 -0.87 -2.76 8.5e-03 3.63e-10 3.83e-01 5.76e-03 1e+00 3.07e-06 1e+00 1e+00 PDF
ENSG00000116824 CD2 -4.64 -5.78 -3.12 -5.01 3.53e-06 7.6e-09 1.8e-03 5.5e-07 2.97e-02 6.41e-05 1e+00 4.67e-03 PDF
ENSG00000117091 CD48 -1.7 -5.55 -1.43 -5.72 8.91e-02 2.86e-08 1.52e-01 1.06e-08 1e+00 2.41e-04 1e+00 9.06e-05 PDF
ENSG00000117318 ID3 -8.17 -2.4 1.03 -0.16 3.03e-16 1.64e-02 3.03e-01 8.7e-01 2.59e-12 1e+00 1e+00 1e+00 PDF
ENSG00000117448 AKR1A1 -0.97 -3.33 -2.19 -4.82 3.32e-01 8.67e-04 2.88e-02 1.41e-06 1e+00 1e+00 1e+00 1.19e-02 PDF
ENSG00000117616 RSRP1 -3.98 -4.85 -3.91 -4.98 6.93e-05 1.24e-06 9.2e-05 6.38e-07 5.77e-01 1.03e-02 7.72e-01 5.42e-03 PDF
ENSG00000118503 TNFAIP3 5.93 9.62 5.79 10.29 3.11e-09 6.9e-22 6.95e-09 7.99e-25 2.64e-05 5.89e-18 5.92e-05 6.86e-21 PDF
ENSG00000119138 KLF9 2.22 3.52 4.07 4.96 2.65e-02 4.29e-04 4.78e-05 7.16e-07 1e+00 1e+00 4.02e-01 6.08e-03 PDF
ENSG00000119185 ITGB1BP1 -2 -5.21 -0.14 -1.57 4.56e-02 1.92e-07 8.88e-01 1.16e-01 1e+00 1.61e-03 1e+00 1e+00 PDF
ENSG00000119431 HDHD3 -3.96 -6.53 -5.21 -5.88 7.4e-05 6.44e-11 1.89e-07 3.99e-09 6.16e-01 5.45e-07 1.61e-03 3.41e-05 PDF
ENSG00000119718 EIF2B2 -5.24 -2.16 -1.52 -0.95 1.59e-07 3.1e-02 1.29e-01 3.42e-01 1.35e-03 1e+00 1e+00 1e+00 PDF
ENSG00000120129 DUSP1 3.12 0.37 7.09 8.6 1.81e-03 7.09e-01 1.38e-12 7.82e-18 1e+00 1e+00 1.18e-08 6.71e-14 PDF
ENSG00000120833 SOCS2 7.98 0.27 6.8 -0.54 1.44e-15 7.87e-01 1.08e-11 5.89e-01 1.23e-11 1e+00 9.25e-08 1e+00 PDF
ENSG00000120875 DUSP4 1.63 10.5 -0.45 4.33 1.04e-01 8.57e-26 6.54e-01 1.49e-05 1e+00 7.33e-22 1e+00 1.25e-01 PDF
ENSG00000120913 PDLIM2 -5.22 -3.5 -1.3 -1.44 1.84e-07 4.57e-04 1.94e-01 1.5e-01 1.56e-03 1e+00 1e+00 1e+00 PDF
ENSG00000121858 TNFSF10 -4.55 1.01 -2.31 -2.46 5.4e-06 3.11e-01 2.08e-02 1.41e-02 4.54e-02 1e+00 1e+00 1e+00 PDF
ENSG00000121966 CXCR4 -3.43 8.23 3.08 1.9 6.13e-04 1.81e-16 2.07e-03 5.78e-02 1e+00 1.54e-12 1e+00 1e+00 PDF
ENSG00000122224 LY9 -4.22 -6.57 -3.72 -4.82 2.42e-05 4.93e-11 1.96e-04 1.43e-06 2.02e-01 4.18e-07 1e+00 1.21e-02 PDF
ENSG00000122862 SRGN 0.85 5.31 -3.2 -1.27 3.96e-01 1.08e-07 1.38e-03 2.03e-01 1e+00 9.04e-04 1e+00 1e+00 PDF
ENSG00000123179 EBPL -2.9 -2.61 -2.45 -4.76 3.7e-03 9.05e-03 1.42e-02 1.92e-06 1e+00 1e+00 1e+00 1.62e-02 PDF
ENSG00000123219 CENPK 6.04 5.19 9.52 10.6 1.5e-09 2.11e-07 1.8e-21 2.83e-26 1.27e-05 1.77e-03 1.54e-17 2.43e-22 PDF
ENSG00000123416 TUBA1B -1.66 -6.27 -1.58 1.8 9.76e-02 3.58e-10 1.14e-01 7.13e-02 1e+00 3.03e-06 1e+00 1e+00 PDF
ENSG00000124256 ZBP1 -0.84 4.83 -0.32 0.53 4.02e-01 1.36e-06 7.52e-01 5.94e-01 1e+00 1.13e-02 1e+00 1e+00 PDF
ENSG00000124575 HIST1H1D 5.99 4.43 6.75 3.54 2.11e-09 9.39e-06 1.47e-11 4.04e-04 1.8e-05 7.78e-02 1.26e-07 1e+00 PDF
ENSG00000124588 NQO2 -1.88 -6.41 -2.82 -2.87 5.95e-02 1.43e-10 4.85e-03 4.04e-03 1e+00 1.21e-06 1e+00 1e+00 PDF
ENSG00000124942 AHNAK 7.56 7.97 1.04 5.09 3.97e-14 1.62e-15 2.98e-01 3.53e-07 3.39e-10 1.38e-11 1e+00 3e-03 PDF
ENSG00000125148 MT2A 1.74 5.65 1.74 0.86 8.14e-02 1.61e-08 8.14e-02 3.9e-01 1e+00 1.36e-04 1e+00 1e+00 PDF
ENSG00000125347 IRF1 -5.03 -6.46 -0.21 1.78 4.82e-07 1.05e-10 8.3e-01 7.54e-02 4.07e-03 8.89e-07 1e+00 1e+00 PDF
ENSG00000125384 PTGER2 -0.01 0.56 5.88 0.21 9.89e-01 5.72e-01 4.02e-09 8.37e-01 1e+00 1e+00 3.42e-05 1e+00 PDF
ENSG00000125691 RPL23 -1.9 -5.02 0.71 -2.92 5.79e-02 5.18e-07 4.75e-01 3.53e-03 1e+00 4.34e-03 1e+00 1e+00 PDF
ENSG00000125726 CD70 -1.3 5.41 NaN 1.48 1.93e-01 6.18e-08 Inf 1.38e-01 1e+00 5.2e-04 Inf 1e+00 PDF
ENSG00000125910 S1PR4 -4.06 -4.76 -2.22 -0.33 4.84e-05 1.9e-06 2.67e-02 7.44e-01 4.04e-01 1.59e-02 1e+00 1e+00 PDF
ENSG00000125952 MAX -2.34 -4.56 -0.36 -2 1.95e-02 5.2e-06 7.17e-01 4.52e-02 1e+00 4.32e-02 1e+00 1e+00 PDF
ENSG00000126264 HCST -8.15 -2.94 -5.71 -8.29 3.63e-16 3.29e-03 1.11e-08 1.16e-16 3.11e-12 1e+00 9.43e-05 9.91e-13 PDF
ENSG00000126353 CCR7 -4.36 -9.71 -2.54 -1.75 1.31e-05 2.8e-22 1.1e-02 7.95e-02 1.1e-01 2.4e-18 1e+00 1e+00 PDF
ENSG00000126524 SBDS 4.77 4.52 2.27 5.5 1.88e-06 6.14e-06 2.35e-02 3.78e-08 1.59e-02 5.09e-02 1e+00 3.22e-04 PDF
ENSG00000126709 IFI6 -1.07 5.7 -1.48 1.88 2.86e-01 1.18e-08 1.4e-01 6.01e-02 1e+00 9.96e-05 1e+00 1e+00 PDF
ENSG00000127124 HIVEP3 -5.14 -3.88 -2.67 -3.64 2.81e-07 1.06e-04 7.65e-03 2.76e-04 2.37e-03 8.63e-01 1e+00 1e+00 PDF
ENSG00000127528 KLF2 -1.97 -3.93 -3.07 -5.59 4.84e-02 8.35e-05 2.15e-03 2.27e-08 1e+00 6.82e-01 1e+00 1.94e-04 PDF
ENSG00000128016 ZFP36 6.8 -0.86 -5.04 -3.24 1.05e-11 3.91e-01 4.58e-07 1.18e-03 8.99e-08 1e+00 3.89e-03 1e+00 PDF
ENSG00000128536 CDHR3 2 4.85 -0.53 1.91 4.5e-02 1.24e-06 5.96e-01 5.56e-02 1e+00 1.03e-02 1e+00 1e+00 PDF
ENSG00000128731 HERC2 -1.36 -2.14 -2.78 -4.57 1.74e-01 3.22e-02 5.39e-03 4.78e-06 1e+00 1e+00 1e+00 4.04e-02 PDF
ENSG00000129824 RPS4Y1 -0.65 -8.69 -1.2 0.32 5.18e-01 3.65e-18 2.3e-01 7.51e-01 1e+00 3.11e-14 1e+00 1e+00 PDF
ENSG00000130066 SAT1 -2.57 -6.84 -1 -3.2 1.03e-02 8.01e-12 3.15e-01 1.39e-03 1e+00 6.8e-08 1e+00 1e+00 PDF
ENSG00000130312 MRPL34 -4.07 -4.31 -4.05 -4.77 4.65e-05 1.63e-05 5.09e-05 1.81e-06 3.88e-01 1.35e-01 4.28e-01 1.53e-02 PDF
ENSG00000130592 LSP1 0.97 8.11 1.91 -0.03 3.33e-01 4.95e-16 5.67e-02 9.75e-01 1e+00 4.22e-12 1e+00 1e+00 PDF
ENSG00000131981 LGALS3 1.16 11.38 0.18 3.33 2.47e-01 5.33e-30 8.6e-01 8.62e-04 1e+00 4.56e-26 1e+00 1e+00 PDF
ENSG00000132199 ENOSF1 -2.81 -2.08 -0.41 -4.89 4.96e-03 3.77e-02 6.84e-01 9.85e-07 1e+00 1e+00 1e+00 8.36e-03 PDF
ENSG00000132406 TMEM128 -5.07 -4.8 -4.06 -3.73 3.89e-07 1.58e-06 4.85e-05 1.9e-04 3.29e-03 1.31e-02 4.08e-01 1e+00 PDF
ENSG00000132965 ALOX5AP -0.35 -1.43 -4.96 -4.43 7.26e-01 1.52e-01 7.04e-07 9.34e-06 1e+00 1e+00 5.97e-03 7.88e-02 PDF
ENSG00000133321 RARRES3 -7.95 -9.55 -1.92 -3.96 1.8e-15 1.33e-21 5.46e-02 7.55e-05 1.54e-11 1.13e-17 1e+00 6.32e-01 PDF
ENSG00000133561 GIMAP6 -7.96 -5.95 -2.43 -1.54 1.71e-15 2.63e-09 1.52e-02 1.24e-01 1.46e-11 2.22e-05 1e+00 1e+00 PDF
ENSG00000133574 GIMAP4 -9.29 -16.84 -5.52 -8.73 1.56e-20 1.32e-63 3.37e-08 2.63e-18 1.34e-16 1.13e-59 2.87e-04 2.25e-14 PDF
ENSG00000134882 UBAC2 -0.4 -4.53 0.96 -0.87 6.86e-01 5.9e-06 3.38e-01 3.83e-01 1e+00 4.9e-02 1e+00 1e+00 PDF
ENSG00000134905 CARS2 -1.87 -4.61 -1.76 -0.68 6.2e-02 3.98e-06 7.89e-02 4.97e-01 1e+00 3.31e-02 1e+00 1e+00 PDF
ENSG00000135046 ANXA1 -7.58 -5.94 -9.33 0.53 3.56e-14 2.87e-09 1.05e-20 5.97e-01 3.04e-10 2.42e-05 8.95e-17 1e+00 PDF
ENSG00000135048 CEMIP2 6.16 4.39 4.04 2.6 7.38e-10 1.15e-05 5.31e-05 9.45e-03 6.28e-06 9.55e-02 4.46e-01 1e+00 PDF
ENSG00000135318 NT5E 4.68 5.93 2.74 2.17 2.93e-06 2.96e-09 6.08e-03 3.02e-02 2.46e-02 2.5e-05 1e+00 1e+00 PDF
ENSG00000135916 ITM2C -2.72 12.83 -2.84 2.68 6.54e-03 1.06e-37 4.58e-03 7.34e-03 1e+00 9.06e-34 1e+00 1e+00 PDF
ENSG00000136152 COG3 2.22 4.93 2.22 2.5 2.63e-02 8.14e-07 2.67e-02 1.25e-02 1e+00 6.81e-03 1e+00 1e+00 PDF
ENSG00000136213 CHST12 -5.62 -1.96 -3.88 -2 1.87e-08 4.98e-02 1.04e-04 4.55e-02 1.59e-04 1e+00 8.73e-01 1e+00 PDF
ENSG00000136490 LIMD2 -7.74 -8.97 -4.76 -6.6 1.02e-14 3.06e-19 1.97e-06 4.01e-11 8.72e-11 2.61e-15 1.67e-02 3.43e-07 PDF
ENSG00000136738 STAM 1.42 5.52 1.75 2.16 1.56e-01 3.36e-08 8.08e-02 3.08e-02 1e+00 2.83e-04 1e+00 1e+00 PDF
ENSG00000136810 TXN 5 2.58 -1.13 2.7 5.65e-07 9.91e-03 2.6e-01 6.86e-03 4.77e-03 1e+00 1e+00 1e+00 PDF
ENSG00000137038 DMAC1 -1.37 -2.88 0.64 -5.13 1.72e-01 4.02e-03 5.22e-01 2.95e-07 1e+00 1e+00 1e+00 2.51e-03 PDF
ENSG00000137078 SIT1 -4.17 -4.9 -3.7 -5.15 3.06e-05 9.81e-07 2.15e-04 2.63e-07 2.56e-01 8.19e-03 1e+00 2.24e-03 PDF
ENSG00000137171 KLC4 -1.23 0.08 -0.2 -4.88 2.2e-01 9.34e-01 8.4e-01 1.05e-06 1e+00 1e+00 1e+00 8.87e-03 PDF
ENSG00000137193 PIM1 8.78 2.11 8.55 -0.76 1.61e-18 3.44e-02 1.19e-17 4.46e-01 1.38e-14 1e+00 1.02e-13 1e+00 PDF
ENSG00000137714 FDX1 -2.36 -0.25 -5.64 -3.64 1.8e-02 8e-01 1.71e-08 2.74e-04 1e+00 1e+00 1.45e-04 1e+00 PDF
ENSG00000138172 CALHM2 -1.62 -4.9 -2.13 -0.62 1.05e-01 9.82e-07 3.32e-02 5.34e-01 1e+00 8.21e-03 1e+00 1e+00 PDF
ENSG00000138185 ENTPD1 1.05 9.3 NaN 3.05 2.95e-01 1.46e-20 Inf 2.27e-03 1e+00 1.24e-16 Inf 1e+00 PDF
ENSG00000138378 STAT4 0.72 -5.08 -2.99 -2.79 4.74e-01 3.87e-07 2.8e-03 5.22e-03 1e+00 3.25e-03 1e+00 1e+00 PDF
ENSG00000138640 FAM13A 5.66 -2.15 9.02 1.59 1.49e-08 3.17e-02 1.94e-19 1.11e-01 1.27e-04 1e+00 1.66e-15 1e+00 PDF
ENSG00000138757 G3BP2 2.92 4.9 0.75 1.58 3.5e-03 9.73e-07 4.55e-01 1.14e-01 1e+00 8.13e-03 1e+00 1e+00 PDF
ENSG00000138795 LEF1 -3.39 -5.39 2.21 0.41 6.88e-04 7.06e-08 2.74e-02 6.79e-01 1e+00 5.94e-04 1e+00 1e+00 PDF
ENSG00000139187 KLRG1 -8.43 0.68 -2.41 0.52 3.6e-17 4.98e-01 1.59e-02 6.03e-01 3.08e-13 1e+00 1e+00 1e+00 PDF
ENSG00000139192 TAPBPL -4.66 -4.03 -3.03 -1.26 3.18e-06 5.64e-05 2.48e-03 2.08e-01 2.68e-02 4.62e-01 1e+00 1e+00 PDF
ENSG00000139289 PHLDA1 -1.96 4.86 NaN 1.26 4.97e-02 1.19e-06 Inf 2.08e-01 1e+00 9.9e-03 Inf 1e+00 PDF
ENSG00000139626 ITGB7 4.65 1.23 2.79 -0.35 3.27e-06 2.18e-01 5.34e-03 7.25e-01 2.75e-02 1e+00 1e+00 1e+00 PDF
ENSG00000139641 ESYT1 0.67 4.54 0.65 -0.96 5.05e-01 5.6e-06 5.18e-01 3.37e-01 1e+00 4.66e-02 1e+00 1e+00 PDF
ENSG00000139679 LPAR6 0.11 0.76 -2.44 -5.19 9.11e-01 4.49e-01 1.48e-02 2.13e-07 1e+00 1e+00 1e+00 1.81e-03 PDF
ENSG00000140319 SRP14 1.98 5.08 1.32 1.27 4.75e-02 3.75e-07 1.86e-01 2.04e-01 1e+00 3.15e-03 1e+00 1e+00 PDF
ENSG00000140931 CMTM3 3.88 6.87 1.67 2.99 1.05e-04 6.43e-12 9.47e-02 2.8e-03 8.73e-01 5.46e-08 1e+00 1e+00 PDF
ENSG00000141232 TOB1 3.76 0.74 6.46 2.87 1.71e-04 4.59e-01 1.07e-10 4.12e-03 1e+00 1e+00 9.1e-07 1e+00 PDF
ENSG00000141556 TBCD 0.61 5.37 1.85 3.59 5.43e-01 7.88e-08 6.42e-02 3.35e-04 1e+00 6.62e-04 1e+00 1e+00 PDF
ENSG00000141682 PMAIP1 2.92 6.96 1.73 3.14 3.55e-03 3.45e-12 8.43e-02 1.71e-03 1e+00 2.93e-08 1e+00 1e+00 PDF
ENSG00000141959 PFKL 6.43 4.12 3.11 0.66 1.28e-10 3.73e-05 1.84e-03 5.08e-01 1.09e-06 3.07e-01 1e+00 1e+00 PDF
ENSG00000142188 TMEM50B -5.67 -2.79 -5.7 -3.78 1.46e-08 5.33e-03 1.23e-08 1.55e-04 1.24e-04 1e+00 1.05e-04 1e+00 PDF
ENSG00000142546 NOSIP -5.34 -5.33 1.03 -3.6 9.22e-08 1.01e-07 3.04e-01 3.2e-04 7.82e-04 8.47e-04 1e+00 1e+00 PDF
ENSG00000142669 SH3BGRL3 4.13 8.62 -0.36 2.36 3.69e-05 6.81e-18 7.19e-01 1.83e-02 3.08e-01 5.8e-14 1e+00 1e+00 PDF
ENSG00000143106 PSMA5 -4.37 -5.88 -3.12 -3.06 1.23e-05 4.03e-09 1.83e-03 2.21e-03 1.03e-01 3.4e-05 1e+00 1e+00 PDF
ENSG00000143198 MGST3 7.83 10.96 6.27 7.72 4.82e-15 5.69e-28 3.72e-10 1.15e-14 4.13e-11 4.87e-24 3.17e-06 9.88e-11 PDF
ENSG00000143641 GALNT2 -1.78 3.67 5.58 4.35 7.58e-02 2.44e-04 2.46e-08 1.33e-05 1e+00 1e+00 2.1e-04 1.12e-01 PDF
ENSG00000144655 CSRNP1 5.43 5.22 3.11 3.56 5.61e-08 1.75e-07 1.87e-03 3.73e-04 4.76e-04 1.47e-03 1e+00 1e+00 PDF
ENSG00000144746 ARL6IP5 0.42 -1.62 -1 -5.75 6.76e-01 1.06e-01 3.19e-01 8.75e-09 1e+00 1e+00 1e+00 7.47e-05 PDF
ENSG00000145220 LYAR -5.2 -5.31 -2.1 -0.87 1.98e-07 1.1e-07 3.54e-02 3.87e-01 1.67e-03 9.27e-04 1e+00 1e+00 PDF
ENSG00000145391 SETD7 -1.15 4.6 -0.03 1.4 2.51e-01 4.18e-06 9.73e-01 1.61e-01 1e+00 3.47e-02 1e+00 1e+00 PDF
ENSG00000145649 GZMA -19.62 -8.96 4.38 -1.54 1.13e-85 3.23e-19 1.21e-05 1.24e-01 9.76e-82 2.76e-15 1.02e-01 1e+00 PDF
ENSG00000145736 GTF2H2 -2.24 -4.29 -1.71 -4.73 2.52e-02 1.77e-05 8.74e-02 2.25e-06 1e+00 1.46e-01 1e+00 1.91e-02 PDF
ENSG00000145779 TNFAIP8 -1.81 -7.34 0.78 -2.57 7.03e-02 2.12e-13 4.33e-01 1.03e-02 1e+00 1.8e-09 1e+00 1e+00 PDF
ENSG00000145860 RNF145 2.68 5.15 0.12 1.91 7.45e-03 2.67e-07 9.03e-01 5.62e-02 1e+00 2.24e-03 1e+00 1e+00 PDF
ENSG00000145945 FAM50B -4.99 -4.35 -2.68 -3.13 5.97e-07 1.39e-05 7.44e-03 1.77e-03 5.05e-03 1.15e-01 1e+00 1e+00 PDF
ENSG00000147138 GPR174 -1.44 -1.29 -5.31 -2.98 1.5e-01 1.99e-01 1.1e-07 2.87e-03 1e+00 1e+00 9.36e-04 1e+00 PDF
ENSG00000147813 NAPRT 2.94 4.31 3.97 4.83 3.26e-03 1.61e-05 7.28e-05 1.35e-06 1e+00 1.33e-01 6.11e-01 1.15e-02 PDF
ENSG00000150347 ARID5B 0.22 6.42 6.23 4.02 8.23e-01 1.38e-10 4.64e-10 5.82e-05 1e+00 1.17e-06 3.96e-06 4.88e-01 PDF
ENSG00000150593 PDCD4 -2.85 -6.33 -1.58 -2.42 4.37e-03 2.45e-10 1.14e-01 1.54e-02 1e+00 2.07e-06 1e+00 1e+00 PDF
ENSG00000150753 CCT5 -2.12 -4.75 -2.22 -1.87 3.44e-02 2.04e-06 2.64e-02 6.1e-02 1e+00 1.7e-02 1e+00 1e+00 PDF
ENSG00000152518 ZFP36L2 4.77 -0.75 6.83 3.16 1.8e-06 4.51e-01 8.28e-12 1.56e-03 1.52e-02 1e+00 7.07e-08 1e+00 PDF
ENSG00000154165 GPR15 6.46 13.39 0.28 3.53 1.04e-10 6.9e-41 7.8e-01 4.21e-04 8.87e-07 5.91e-37 1e+00 1e+00 PDF
ENSG00000154229 PRKCA -1.78 -4.58 0.81 -1.01 7.48e-02 4.62e-06 4.17e-01 3.14e-01 1e+00 3.84e-02 1e+00 1e+00 PDF
ENSG00000154451 GBP5 -0.85 7.58 0.42 1.53 3.93e-01 3.59e-14 6.78e-01 1.26e-01 1e+00 3.05e-10 1e+00 1e+00 PDF
ENSG00000154767 XPC -5.19 -1.46 -2.61 0.39 2.13e-07 1.45e-01 8.99e-03 6.98e-01 1.81e-03 1e+00 1e+00 1e+00 PDF
ENSG00000155959 VBP1 -3.35 -5.47 -1.62 0.76 8.16e-04 4.57e-08 1.05e-01 4.49e-01 1e+00 3.85e-04 1e+00 1e+00 PDF
ENSG00000156976 EIF4A2 -3.69 -6.03 -2.23 -2.46 2.2e-04 1.65e-09 2.61e-02 1.38e-02 1e+00 1.39e-05 1e+00 1e+00 PDF
ENSG00000157514 TSC22D3 1.95 9.94 6.28 13.48 5.08e-02 2.92e-23 3.28e-10 1.95e-41 1e+00 2.5e-19 2.8e-06 1.68e-37 PDF
ENSG00000158517 NCF1 -0.9 8.99 -0.36 -1.1 3.71e-01 2.39e-19 7.17e-01 2.73e-01 1e+00 2.04e-15 1e+00 1e+00 PDF
ENSG00000158525 CPA5 -5.66 -10.04 -3.52 -6.82 1.48e-08 1.01e-23 4.28e-04 8.91e-12 1.26e-04 8.66e-20 1e+00 7.63e-08 PDF
ENSG00000158710 TAGLN2 4.79 2.56 2.3 5.75 1.71e-06 1.04e-02 2.13e-02 9.07e-09 1.44e-02 1e+00 1e+00 7.75e-05 PDF
ENSG00000158813 EDA 2.35 0.33 5.03 2.44 1.9e-02 7.44e-01 4.96e-07 1.46e-02 1e+00 1e+00 4.21e-03 1e+00 PDF
ENSG00000159388 BTG2 -0.2 -5.52 -1.49 -3.53 8.45e-01 3.47e-08 1.37e-01 4.16e-04 1e+00 2.92e-04 1e+00 1e+00 PDF
ENSG00000160185 UBASH3A -2.66 -6.34 -0.57 -5.34 7.87e-03 2.3e-10 5.68e-01 9.21e-08 1e+00 1.94e-06 1e+00 7.85e-04 PDF
ENSG00000160213 CSTB 2.97 4.87 -1.57 -0.94 2.96e-03 1.09e-06 1.16e-01 3.46e-01 1e+00 9.09e-03 1e+00 1e+00 PDF
ENSG00000160888 IER2 5.84 -11.09 4.83 0.84 5.15e-09 1.46e-28 1.38e-06 3.99e-01 4.38e-05 1.25e-24 1.17e-02 1e+00 PDF
ENSG00000161547 SRSF2 7.86 7.7 11.03 10.64 3.74e-15 1.41e-14 2.86e-28 1.92e-26 3.2e-11 1.2e-10 2.45e-24 1.65e-22 PDF
ENSG00000162704 ARPC5 -6.13 -5.55 -6.62 -5.03 8.99e-10 2.8e-08 3.65e-11 4.95e-07 7.65e-06 2.35e-04 3.11e-07 4.21e-03 PDF
ENSG00000162777 DENND2D -10.16 -8.05 -7.5 -5.85 3.02e-24 7.95e-16 6.28e-14 5e-09 2.59e-20 6.77e-12 5.36e-10 4.27e-05 PDF
ENSG00000163131 CTSS -0.61 5.49 -1.88 -1.66 5.4e-01 3.93e-08 6.05e-02 9.6e-02 1e+00 3.31e-04 1e+00 1e+00 PDF
ENSG00000163154 TNFAIP8L2 -3.91 -6.83 -4.59 -4.85 9.12e-05 8.41e-12 4.34e-06 1.25e-06 7.58e-01 7.13e-08 3.67e-02 1.06e-02 PDF
ENSG00000163319 MRPS18C -0.08 -0.93 4.8 2.23 9.38e-01 3.53e-01 1.59e-06 2.57e-02 1e+00 1e+00 1.35e-02 1e+00 PDF
ENSG00000163463 KRTCAP2 -0.16 0.11 -4.79 -0.93 8.74e-01 9.14e-01 1.64e-06 3.5e-01 1e+00 1e+00 1.39e-02 1e+00 PDF
ENSG00000163513 TGFBR2 -3.08 -4.66 0.2 -1.75 2.06e-03 3.13e-06 8.43e-01 8.02e-02 1e+00 2.61e-02 1e+00 1e+00 PDF
ENSG00000163519 TRAT1 -3.72 -2.88 -3.5 -6.15 1.98e-04 4e-03 4.66e-04 7.57e-10 1e+00 1e+00 1e+00 6.47e-06 PDF
ENSG00000163565 IFI16 -3.11 -5.28 -0.21 -1.61 1.88e-03 1.27e-07 8.32e-01 1.08e-01 1e+00 1.06e-03 1e+00 1e+00 PDF
ENSG00000163599 CTLA4 3.18 9.25 0.98 4.21 1.45e-03 2.35e-20 3.25e-01 2.53e-05 1e+00 2e-16 1e+00 2.13e-01 PDF
ENSG00000163870 TPRA1 -4.94 -2.74 -2.41 -4.61 7.62e-07 6.15e-03 1.6e-02 3.95e-06 6.43e-03 1e+00 1e+00 3.34e-02 PDF
ENSG00000164032 H2AFZ -1.92 -7.75 -3.35 -2.49 5.51e-02 9.06e-15 8.05e-04 1.26e-02 1e+00 7.71e-11 1e+00 1e+00 PDF
ENSG00000164442 CITED2 6.37 4.39 0.21 -2.7 1.84e-10 1.14e-05 8.37e-01 6.96e-03 1.57e-06 9.41e-02 1e+00 1e+00 PDF
ENSG00000164543 STK17A -3.33 -1.84 -6.99 -1.47 8.84e-04 6.6e-02 2.77e-12 1.42e-01 1e+00 1e+00 2.37e-08 1e+00 PDF
ENSG00000165272 AQP3 4.73 2.83 1.16 1.01 2.28e-06 4.63e-03 2.44e-01 3.12e-01 1.92e-02 1e+00 1e+00 1e+00 PDF
ENSG00000165630 PRPF18 -4.73 -0.5 -1.28 -2.41 2.26e-06 6.16e-01 2e-01 1.58e-02 1.91e-02 1e+00 1e+00 1e+00 PDF
ENSG00000165644 COMTD1 4.65 -0.06 0.19 -0.89 3.39e-06 9.55e-01 8.48e-01 3.76e-01 2.85e-02 1e+00 1e+00 1e+00 PDF
ENSG00000165672 PRDX3 -2.3 -8.06 -1.94 -4.33 2.13e-02 7.63e-16 5.22e-02 1.46e-05 1e+00 6.5e-12 1e+00 1.23e-01 PDF
ENSG00000165714 BORCS5 -0.64 -5.54 -0.72 -1.58 5.25e-01 3.01e-08 4.73e-01 1.14e-01 1e+00 2.53e-04 1e+00 1e+00 PDF
ENSG00000165929 TC2N -5.43 -2.74 -3.85 -1.19 5.67e-08 6.08e-03 1.2e-04 2.35e-01 4.81e-04 1e+00 1e+00 1e+00 PDF
ENSG00000166557 TMED3 -0.25 -1.84 -5.14 -2.84 8.06e-01 6.59e-02 2.79e-07 4.46e-03 1e+00 1e+00 2.37e-03 1e+00 PDF
ENSG00000166750 SLFN5 -4.26 -7.03 1.7 -0.55 2.03e-05 2.02e-12 8.85e-02 5.83e-01 1.7e-01 1.72e-08 1e+00 1e+00 PDF
ENSG00000167618 LAIR2 6.69 15.19 6.74 9.03 2.23e-11 4.42e-52 1.57e-11 1.64e-19 1.9e-07 3.8e-48 1.34e-07 1.41e-15 PDF
ENSG00000167851 CD300A -5.04 -2.65 -0.96 -1 4.68e-07 8.02e-03 3.37e-01 3.17e-01 3.95e-03 1e+00 1e+00 1e+00 PDF
ENSG00000167996 FTH1 11.15 13.97 0.79 -0.96 6.89e-29 2.23e-44 4.27e-01 3.36e-01 5.91e-25 1.91e-40 1e+00 1e+00 PDF
ENSG00000168209 DDIT4 15.55 12.63 11.16 12.86 1.61e-54 1.53e-36 6.09e-29 7.74e-38 1.38e-50 1.31e-32 5.22e-25 6.65e-34 PDF
ENSG00000168275 COA6 -2.41 -4.79 -2.28 -1.96 1.6e-02 1.64e-06 2.24e-02 5.01e-02 1e+00 1.37e-02 1e+00 1e+00 PDF
ENSG00000168298 HIST1H1E 5.05 4.11 3.87 2.33 4.34e-07 3.95e-05 1.1e-04 1.96e-02 3.67e-03 3.24e-01 9.22e-01 1e+00 PDF
ENSG00000168569 TMEM223 -3.86 -2.93 -1.28 -4.57 1.12e-04 3.42e-03 1.99e-01 4.8e-06 9.27e-01 1e+00 1e+00 4.06e-02 PDF
ENSG00000168685 IL7R -7.38 -5.86 -5.16 -0.25 1.63e-13 4.62e-09 2.46e-07 8e-01 1.39e-09 3.9e-05 2.09e-03 1e+00 PDF
ENSG00000168765 GSTM4 3.19 4.55 4.39 5.99 1.42e-03 5.47e-06 1.12e-05 2.05e-09 1e+00 4.55e-02 9.48e-02 1.75e-05 PDF
ENSG00000168918 INPP5D -7.06 -1.9 -0.75 -4.29 1.72e-12 5.8e-02 4.53e-01 1.77e-05 1.47e-08 1e+00 1e+00 1.49e-01 PDF
ENSG00000169220 RGS14 -4.58 -3.78 -3.68 -3.19 4.68e-06 1.55e-04 2.32e-04 1.41e-03 3.94e-02 1e+00 1e+00 1e+00 PDF
ENSG00000169508 GPR183 -6.48 -0.77 -1.74 -4.33 9.25e-11 4.41e-01 8.2e-02 1.52e-05 7.88e-07 1e+00 1e+00 1.28e-01 PDF
ENSG00000169756 LIMS1 0.48 -5.9 -1.64 -2.43 6.3e-01 3.69e-09 1.02e-01 1.5e-02 1e+00 3.11e-05 1e+00 1e+00 PDF
ENSG00000169813 HNRNPF -5.55 -7.6 -6.33 -4.43 2.87e-08 2.98e-14 2.53e-10 9.22e-06 2.44e-04 2.53e-10 2.16e-06 7.78e-02 PDF
ENSG00000170128 GPR25 -5.35 -3.61 -0.13 0.1 8.93e-08 3.03e-04 8.99e-01 9.17e-01 7.58e-04 1e+00 1e+00 1e+00 PDF
ENSG00000170345 FOS -9.87 -12.03 -0.21 -11.97 5.75e-23 2.48e-33 8.37e-01 5.18e-33 4.93e-19 2.12e-29 1e+00 4.45e-29 PDF
ENSG00000170542 SERPINB9 -4.41 -4.05 -1.31 -5.08 1.02e-05 5.05e-05 1.91e-01 3.77e-07 8.55e-02 4.14e-01 1e+00 3.2e-03 PDF
ENSG00000170989 S1PR1 -5.56 -3.83 -1.33 -0.62 2.76e-08 1.3e-04 1.82e-01 5.36e-01 2.35e-04 1e+00 1e+00 1e+00 PDF
ENSG00000171115 GIMAP8 -2.38 -4.72 0.83 -2.52 1.72e-02 2.37e-06 4.05e-01 1.18e-02 1e+00 1.97e-02 1e+00 1e+00 PDF
ENSG00000171223 JUNB 6.54 -10.28 0.74 -17.4 6.33e-11 9.09e-25 4.58e-01 8.99e-68 5.4e-07 7.77e-21 1e+00 7.73e-64 PDF
ENSG00000171840 NINJ2 0.98 12.59 1.22 2.04 3.27e-01 2.55e-36 2.22e-01 4.11e-02 1e+00 2.19e-32 1e+00 1e+00 PDF
ENSG00000172005 MAL 5.69 2.1 2.96 1.27 1.29e-08 3.61e-02 3.1e-03 2.04e-01 1.1e-04 1e+00 1e+00 1e+00 PDF
ENSG00000172216 CEBPB -5.57 -2.77 0.05 -1.35 2.53e-08 5.64e-03 9.62e-01 1.76e-01 2.14e-04 1e+00 1e+00 1e+00 PDF
ENSG00000172349 IL16 -4.93 -7.59 -2.56 -4.66 8.42e-07 3.15e-14 1.05e-02 3.19e-06 7.1e-03 2.68e-10 1e+00 2.7e-02 PDF
ENSG00000172354 GNB2 2.3 4.96 2.76 1.17 2.17e-02 6.95e-07 5.79e-03 2.44e-01 1e+00 5.81e-03 1e+00 1e+00 PDF
ENSG00000172757 CFL1 0.7 -2.57 -4.78 -1.2 4.83e-01 1.01e-02 1.76e-06 2.29e-01 1e+00 1e+00 1.49e-02 1e+00 PDF
ENSG00000172965 MIR4435-2HG -0.16 5.1 0.99 2.63 8.72e-01 3.34e-07 3.2e-01 8.53e-03 1e+00 2.8e-03 1e+00 1e+00 PDF
ENSG00000173114 LRRN3 7.86 3.76 12.71 3.29 3.82e-15 1.7e-04 5.19e-37 9.94e-04 3.27e-11 1e+00 4.45e-33 1e+00 PDF
ENSG00000173762 CD7 5.84 3.96 2.75 2.28 5.17e-09 7.53e-05 6.01e-03 2.24e-02 4.4e-05 6.16e-01 1e+00 1e+00 PDF
ENSG00000173889 PHC3 -5.05 0.39 -1.79 1.55 4.52e-07 6.96e-01 7.4e-02 1.21e-01 3.82e-03 1e+00 1e+00 1e+00 PDF
ENSG00000173917 HOXB2 -5.19 -11.27 -5.83 -9.52 2.15e-07 1.86e-29 5.63e-09 1.78e-21 1.82e-03 1.59e-25 4.8e-05 1.53e-17 PDF
ENSG00000174953 DHX36 -4.97 -2.81 -0.57 -0.4 6.62e-07 4.89e-03 5.66e-01 6.92e-01 5.59e-03 1e+00 1e+00 1e+00 PDF
ENSG00000175463 TBC1D10C -2.02 -5.19 -3.49 -4.16 4.31e-02 2.12e-07 4.8e-04 3.24e-05 1e+00 1.78e-03 1e+00 2.72e-01 PDF
ENSG00000175567 UCP2 -2.86 -4.26 -1.42 -5.4 4.27e-03 2.01e-05 1.55e-01 6.72e-08 1e+00 1.66e-01 1e+00 5.72e-04 PDF
ENSG00000176390 CRLF3 -5.8 -4.02 -4.27 -5.3 6.44e-09 5.71e-05 1.97e-05 1.15e-07 5.47e-05 4.67e-01 1.66e-01 9.82e-04 PDF
ENSG00000177606 JUN 0.94 -7.92 2.16 6.56 3.48e-01 2.46e-15 3.06e-02 5.21e-11 1e+00 2.09e-11 1e+00 4.46e-07 PDF
ENSG00000177721 ANXA2R -3.55 -6.08 -4.16 -3.68 3.89e-04 1.23e-09 3.19e-05 2.31e-04 1e+00 1.04e-05 2.68e-01 1e+00 PDF
ENSG00000177854 TMEM187 -5 -2.39 -1.97 -1.84 5.81e-07 1.69e-02 4.93e-02 6.51e-02 4.91e-03 1e+00 1e+00 1e+00 PDF
ENSG00000178035 IMPDH2 -1.13 -5.68 2.01 0.23 2.6e-01 1.34e-08 4.49e-02 8.17e-01 1e+00 1.13e-04 1e+00 1e+00 PDF
ENSG00000178209 PLEC 4.82 0.82 3.29 3.92 1.47e-06 4.13e-01 9.93e-04 8.82e-05 1.24e-02 1e+00 1e+00 7.38e-01 PDF
ENSG00000178537 SLC25A20 -0.99 -6.76 -2.82 -2.93 3.24e-01 1.37e-11 4.87e-03 3.4e-03 1e+00 1.16e-07 1e+00 1e+00 PDF
ENSG00000178896 EXOSC4 -1.97 -4.98 -0.56 -1.35 4.83e-02 6.31e-07 5.78e-01 1.78e-01 1e+00 5.28e-03 1e+00 1e+00 PDF
ENSG00000178913 TAF7 -5.2 -3.33 -1.28 -2.8 1.96e-07 8.62e-04 2e-01 5.11e-03 1.66e-03 1e+00 1e+00 1e+00 PDF
ENSG00000178927 CYBC1 -1.62 -4.96 -0.75 -1.45 1.05e-01 7.1e-07 4.53e-01 1.48e-01 1e+00 5.94e-03 1e+00 1e+00 PDF
ENSG00000179144 GIMAP7 -15.03 -16.38 -10.75 -11.61 4.61e-51 2.48e-60 5.68e-27 3.62e-31 3.96e-47 2.13e-56 4.86e-23 3.11e-27 PDF
ENSG00000179344 HLA-DQB1 -5.6 6.83 -4.49 -1.17 2.21e-08 8.31e-12 7.25e-06 2.4e-01 1.87e-04 7.05e-08 6.13e-02 1e+00 PDF
ENSG00000179933 C14orf119 -1.3 -5.58 -2.23 -5.46 1.92e-01 2.34e-08 2.6e-02 4.67e-08 1e+00 1.97e-04 1e+00 3.98e-04 PDF
ENSG00000180628 PCGF5 2.2 1.83 5.05 1.7 2.81e-02 6.75e-02 4.45e-07 8.85e-02 1e+00 1e+00 3.78e-03 1e+00 PDF
ENSG00000181284 TMEM102 -1.94 -4.53 -1.51 -1.97 5.27e-02 5.93e-06 1.31e-01 4.84e-02 1e+00 4.92e-02 1e+00 1e+00 PDF
ENSG00000182010 RTKN2 -1.68 2.49 -0.82 5.11 9.36e-02 1.27e-02 4.13e-01 3.17e-07 1e+00 1e+00 1e+00 2.7e-03 PDF
ENSG00000182247 UBE2E2 -2.41 -1.42 -1.81 -5.4 1.6e-02 1.56e-01 6.96e-02 6.53e-08 1e+00 1e+00 1e+00 5.57e-04 PDF
ENSG00000182362 YBEY -3.37 -8.03 -6.68 -5.97 7.59e-04 1.01e-15 2.35e-11 2.41e-09 1e+00 8.64e-12 2e-07 2.06e-05 PDF
ENSG00000182481 KPNA2 -0.21 -6.39 -1.2 2.78 8.37e-01 1.69e-10 2.3e-01 5.51e-03 1e+00 1.43e-06 1e+00 1e+00 PDF
ENSG00000182568 SATB1 -2.14 -4.9 0.73 -4.28 3.26e-02 9.51e-07 4.64e-01 1.88e-05 1e+00 7.95e-03 1e+00 1.58e-01 PDF
ENSG00000182718 ANXA2 9.58 10.39 1.2 7.02 9.8e-22 2.83e-25 2.3e-01 2.29e-12 8.41e-18 2.42e-21 1e+00 1.96e-08 PDF
ENSG00000182809 CRIP2 0.35 -6.91 -4.68 -6.73 7.27e-01 4.88e-12 2.85e-06 1.71e-11 1e+00 4.14e-08 2.41e-02 1.46e-07 PDF
ENSG00000183386 FHL3 5.1 5.84 4.86 5.44 3.41e-07 5.33e-09 1.16e-06 5.24e-08 2.88e-03 4.5e-05 9.82e-03 4.47e-04 PDF
ENSG00000183508 TENT5C 2.05 6.34 1.1 1.64 4e-02 2.25e-10 2.69e-01 1.01e-01 1e+00 1.9e-06 1e+00 1e+00 PDF
ENSG00000183691 NOG -0.69 -4.79 -5.07 -5.26 4.92e-01 1.71e-06 4.04e-07 1.42e-07 1e+00 1.42e-02 3.43e-03 1.21e-03 PDF
ENSG00000184205 TSPYL2 0.41 0.38 2 5.26 6.84e-01 7.04e-01 4.56e-02 1.47e-07 1e+00 1e+00 1e+00 1.25e-03 PDF
ENSG00000184432 COPB2 -0.71 -5.41 -1.91 -0.72 4.8e-01 6.19e-08 5.58e-02 4.7e-01 1e+00 5.2e-04 1e+00 1e+00 PDF
ENSG00000184451 CCR10 1.7 4.2 NaN 4.76 8.86e-02 2.73e-05 Inf 1.92e-06 1e+00 2.25e-01 Inf 1.63e-02 PDF
ENSG00000184557 SOCS3 0.71 -1.32 0.31 -6.08 4.76e-01 1.85e-01 7.59e-01 1.23e-09 1e+00 1e+00 1e+00 1.05e-05 PDF
ENSG00000184897 H1FX 0.3 4.93 0.87 1.28 7.67e-01 8.3e-07 3.86e-01 2e-01 1e+00 6.94e-03 1e+00 1e+00 PDF
ENSG00000184898 RBM43 -6.23 -2.29 -2.5 -2.15 4.61e-10 2.2e-02 1.25e-02 3.19e-02 3.92e-06 1e+00 1e+00 1e+00 PDF
ENSG00000184939 ZFP90 -1.58 -2.09 -3.56 -4.79 1.15e-01 3.67e-02 3.67e-04 1.65e-06 1e+00 1e+00 1e+00 1.39e-02 PDF
ENSG00000185201 IFITM2 9.63 2.75 4.66 5.14 6.18e-22 5.91e-03 3.16e-06 2.8e-07 5.3e-18 1e+00 2.67e-02 2.38e-03 PDF
ENSG00000185338 SOCS1 5.04 0.92 3.35 2.73 4.66e-07 3.55e-01 7.97e-04 6.41e-03 3.94e-03 1e+00 1e+00 1e+00 PDF
ENSG00000185811 IKZF1 -6.53 -3.74 -1.93 -0.57 6.45e-11 1.81e-04 5.41e-02 5.67e-01 5.5e-07 1e+00 1e+00 1e+00 PDF
ENSG00000185885 IFITM1 12.94 3.23 6.1 3.47 2.71e-38 1.23e-03 1.06e-09 5.18e-04 2.33e-34 1e+00 9.01e-06 1e+00 PDF
ENSG00000186174 BCL9L -5.1 0.87 -0.4 -0.71 3.43e-07 3.85e-01 6.87e-01 4.75e-01 2.9e-03 1e+00 1e+00 1e+00 PDF
ENSG00000186810 CXCR3 -6.73 -7.65 -1.89 -4.55 1.75e-11 2.02e-14 5.93e-02 5.31e-06 1.49e-07 1.72e-10 1e+00 4.49e-02 PDF
ENSG00000186827 TNFRSF4 4.7 1.7 -1.23 1.93 2.54e-06 8.83e-02 2.17e-01 5.32e-02 2.14e-02 1e+00 1e+00 1e+00 PDF
ENSG00000187257 RSBN1L -3.21 -6.4 -2.72 -4.35 1.34e-03 1.51e-10 6.45e-03 1.39e-05 1e+00 1.27e-06 1e+00 1.17e-01 PDF
ENSG00000188042 ARL4C -1.94 -3.34 -0.13 -6.33 5.27e-02 8.39e-04 8.96e-01 2.38e-10 1e+00 1e+00 1e+00 2.03e-06 PDF
ENSG00000188389 PDCD1 4.61 0.3 NaN 0.09 3.96e-06 7.61e-01 Inf 9.29e-01 3.33e-02 1e+00 Inf 1e+00 PDF
ENSG00000188404 SELL -4.26 -3.8 -5.05 -4.89 2.01e-05 1.43e-04 4.48e-07 1.03e-06 1.68e-01 1e+00 3.8e-03 8.7e-03 PDF
ENSG00000188820 CALHM6 4.57 3.8 9.99 5.48 4.78e-06 1.44e-04 1.66e-23 4.28e-08 4.02e-02 1e+00 1.42e-19 3.65e-04 PDF
ENSG00000189180 ZNF33A -2.58 0.06 -0.37 -4.9 9.95e-03 9.52e-01 7.08e-01 9.8e-07 1e+00 1e+00 1e+00 8.32e-03 PDF
ENSG00000189266 PNRC2 -2.21 -4.95 -0.78 -0.05 2.72e-02 7.26e-07 4.33e-01 9.61e-01 1e+00 6.07e-03 1e+00 1e+00 PDF
ENSG00000189283 FHIT 0.52 3.78 2.64 4.59 6.01e-01 1.59e-04 8.37e-03 4.48e-06 1e+00 1e+00 1e+00 3.79e-02 PDF
ENSG00000189403 HMGB1 -1.33 -5.08 -0.23 0.63 1.84e-01 3.74e-07 8.19e-01 5.28e-01 1e+00 3.14e-03 1e+00 1e+00 PDF
ENSG00000196126 HLA-DRB1 1.79 8.51 0.11 4.97 7.3e-02 1.77e-17 9.16e-01 6.56e-07 1e+00 1.51e-13 1e+00 5.57e-03 PDF
ENSG00000196154 S100A4 17.91 15.61 -1.1 5.09 9.41e-72 5.99e-55 2.71e-01 3.52e-07 8.09e-68 5.14e-51 1e+00 2.99e-03 PDF
ENSG00000196230 TUBB -3.01 -4.84 -2.07 -2.29 2.63e-03 1.29e-06 3.82e-02 2.19e-02 1e+00 1.07e-02 1e+00 1e+00 PDF
ENSG00000196323 ZBTB44 -1.53 -4.8 -3 -1.02 1.27e-01 1.59e-06 2.66e-03 3.09e-01 1e+00 1.32e-02 1e+00 1e+00 PDF
ENSG00000196329 GIMAP5 -5.2 -3.12 -3.5 -1.58 2.01e-07 1.81e-03 4.57e-04 1.15e-01 1.71e-03 1e+00 1e+00 1e+00 PDF
ENSG00000196421 C20orf204 10.85 2.91 9.5 7.34 2.08e-27 3.59e-03 2.18e-21 2.09e-13 1.78e-23 1e+00 1.87e-17 1.79e-09 PDF
ENSG00000196787 HIST1H2AG 0.76 7.21 1.14 0.11 4.48e-01 5.43e-13 2.55e-01 9.15e-01 1e+00 4.61e-09 1e+00 1e+00 PDF
ENSG00000196924 FLNA 5.25 2.31 3.4 -0.05 1.5e-07 2.11e-02 6.69e-04 9.56e-01 1.27e-03 1e+00 1e+00 1e+00 PDF
ENSG00000197329 PELI1 3.16 5.2 -0.86 5.47 1.55e-03 1.97e-07 3.92e-01 4.42e-08 1e+00 1.65e-03 1e+00 3.77e-04 PDF
ENSG00000197448 GSTK1 4.6 2.36 -0.1 0.05 4.18e-06 1.85e-02 9.18e-01 9.63e-01 3.52e-02 1e+00 1e+00 1e+00 PDF
ENSG00000197498 RPF2 0.53 -4.67 -0.62 -2.02 5.98e-01 3.05e-06 5.36e-01 4.34e-02 1e+00 2.54e-02 1e+00 1e+00 PDF
ENSG00000197540 GZMM -3.41 -4.85 -4.5 -4.89 6.58e-04 1.22e-06 6.92e-06 1e-06 1e+00 1.01e-02 5.85e-02 8.52e-03 PDF
ENSG00000197747 S100A10 10.95 6.76 1.16 4.02 6.86e-28 1.35e-11 2.48e-01 5.71e-05 5.88e-24 1.15e-07 1e+00 4.79e-01 PDF
ENSG00000197928 ZNF677 -6.16 -3.9 -1.13 -2.52 7.05e-10 9.51e-05 2.58e-01 1.17e-02 6.01e-06 7.75e-01 1e+00 1e+00 PDF
ENSG00000197956 S100A6 12.32 13.7 2.35 3.65 7.18e-35 9.83e-43 1.9e-02 2.57e-04 6.17e-31 8.43e-39 1e+00 1e+00 PDF
ENSG00000198189 HSD17B11 -2.76 -1.26 -3.99 -4.77 5.77e-03 2.07e-01 6.48e-05 1.85e-06 1e+00 1e+00 5.44e-01 1.56e-02 PDF
ENSG00000198417 MT1F -5.44 -2.58 -2.62 -2.47 5.24e-08 9.9e-03 8.8e-03 1.33e-02 4.45e-04 1e+00 1e+00 1e+00 PDF
ENSG00000198502 HLA-DRB5 -2.61 -12.38 0.43 -9.96 9.01e-03 3.16e-35 6.7e-01 2.31e-23 1e+00 2.71e-31 1e+00 1.98e-19 PDF
ENSG00000198763 MT-ND2 15.99 5.62 15.06 16.01 1.51e-57 1.94e-08 3.06e-51 1.12e-57 1.3e-53 1.63e-04 2.63e-47 9.67e-54 PDF
ENSG00000198771 RCSD1 -1.3 -4.96 -0.75 -0.47 1.92e-01 7.01e-07 4.54e-01 6.36e-01 1e+00 5.86e-03 1e+00 1e+00 PDF
ENSG00000198805 PNP -5.23 -4.96 -4.76 -3.43 1.68e-07 6.97e-07 1.93e-06 6.01e-04 1.42e-03 5.83e-03 1.63e-02 1e+00 PDF
ENSG00000198830 HMGN2 -1.33 5.8 0.55 1.8 1.82e-01 6.78e-09 5.8e-01 7.22e-02 1e+00 5.72e-05 1e+00 1e+00 PDF
ENSG00000204161 TMEM273 -6.39 -7.37 0 -6.97 1.62e-10 1.77e-13 1e+00 3.26e-12 1.38e-06 1.5e-09 1e+00 2.79e-08 PDF
ENSG00000204261 PSMB8-AS1 -5.22 -5.35 -1.33 -3.57 1.77e-07 8.84e-08 1.83e-01 3.53e-04 1.5e-03 7.43e-04 1e+00 1e+00 PDF
ENSG00000204287 HLA-DRA -0.15 -5.33 -0.17 -1.68 8.84e-01 9.63e-08 8.68e-01 9.37e-02 1e+00 8.1e-04 1e+00 1e+00 PDF
ENSG00000204389 HSPA1A -3.54 -6.49 -4.32 -4.95 4.05e-04 8.38e-11 1.54e-05 7.54e-07 1e+00 7.1e-07 1.3e-01 6.4e-03 PDF
ENSG00000204472 AIF1 -5.78 0.27 -2.65 -8.7 7.29e-09 7.9e-01 8.11e-03 3.46e-18 6.2e-05 1e+00 1e+00 2.96e-14 PDF
ENSG00000205138 SDHAF1 -0.98 -5.69 -3.29 -3.53 3.25e-01 1.28e-08 1.02e-03 4.11e-04 1e+00 1.08e-04 1e+00 1e+00 PDF
ENSG00000205268 PDE7A -2.99 -3.92 -2.84 -4.6 2.82e-03 8.92e-05 4.52e-03 4.27e-06 1e+00 7.27e-01 1e+00 3.61e-02 PDF
ENSG00000205707 ETFRF1 -1.81 -5.16 -3.08 -2.7 7.04e-02 2.51e-07 2.1e-03 7.01e-03 1e+00 2.1e-03 1e+00 1e+00 PDF
ENSG00000211694 TRGV10 -0.21 4.92 1.54 0.22 8.35e-01 8.78e-07 1.25e-01 8.29e-01 1e+00 7.34e-03 1e+00 1e+00 PDF
ENSG00000211706 TRBV6-1 -2.21 -11.09 -3.84 -0.89 2.68e-02 1.45e-28 1.23e-04 3.74e-01 1e+00 1.24e-24 1e+00 1e+00 PDF
ENSG00000211710 TRBV4-1 6.84 19.6 9.22 2.61 8.05e-12 1.55e-85 3.05e-20 9.05e-03 6.87e-08 1.33e-81 2.61e-16 1e+00 PDF
ENSG00000211716 TRBV9 8.67 5.24 -7.83 -3.05 4.18e-18 1.65e-07 4.78e-15 2.3e-03 3.58e-14 1.39e-03 4.09e-11 1e+00 PDF
ENSG00000211721 TRBV6-5 1.84 -4.14 0.65 -12.47 6.55e-02 3.44e-05 5.18e-01 1.04e-35 1e+00 2.83e-01 1e+00 8.95e-32 PDF
ENSG00000211724 TRBV6-6 -6.85 3.32 -4.91 0.04 7.19e-12 9.16e-04 9.26e-07 9.65e-01 6.14e-08 1e+00 7.85e-03 1e+00 PDF
ENSG00000211727 TRBV7-6 0.56 0.93 7.74 -3.4 5.73e-01 3.53e-01 9.92e-15 6.86e-04 1e+00 1e+00 8.48e-11 1e+00 PDF
ENSG00000211734 TRBV5-1 -0.58 3.67 5.74 0.48 5.6e-01 2.46e-04 9.47e-09 6.33e-01 1e+00 1e+00 8.06e-05 1e+00 PDF
ENSG00000211745 TRBV4-2 -8.4 11.56 0.19 -2.81 4.31e-17 6.67e-31 8.52e-01 4.99e-03 3.69e-13 5.71e-27 1e+00 1e+00 PDF
ENSG00000211747 TRBV20-1 -0.7 13.62 3.46 1.5 4.83e-01 3.11e-42 5.38e-04 1.35e-01 1e+00 2.67e-38 1e+00 1e+00 PDF
ENSG00000211751 TRBC1 -5.18 -9.35 -4.02 -0.19 2.24e-07 9.13e-21 5.91e-05 8.47e-01 1.89e-03 7.79e-17 4.96e-01 1e+00 PDF
ENSG00000211753 TRBV28 7.74 10.54 8.47 5.97 9.9e-15 5.89e-26 2.45e-17 2.31e-09 8.46e-11 5.03e-22 2.09e-13 1.97e-05 PDF
ENSG00000211779 TRAV5 2.56 -2.77 -2.09 -5.47 1.06e-02 5.67e-03 3.66e-02 4.51e-08 1e+00 1e+00 1e+00 3.85e-04 PDF
ENSG00000211780 TRAV6 -2.08 -5.21 -3.68 -3.89 3.76e-02 1.93e-07 2.3e-04 9.97e-05 1e+00 1.62e-03 1e+00 8.34e-01 PDF
ENSG00000211782 TRAV8-1 -0.44 -8.29 -5.16 -3.85 6.61e-01 1.15e-16 2.49e-07 1.16e-04 1e+00 9.83e-13 2.11e-03 9.71e-01 PDF
ENSG00000211786 TRAV8-2 -4.76 -5.04 -4.88 -6.51 1.95e-06 4.6e-07 1.04e-06 7.38e-11 1.64e-02 3.86e-03 8.83e-03 6.31e-07 PDF
ENSG00000211788 TRAV13-1 -5.8 -4.56 -2.73 -2.73 6.64e-09 5.07e-06 6.36e-03 6.27e-03 5.64e-05 4.22e-02 1e+00 1e+00 PDF
ENSG00000211789 TRAV12-2 2.42 13.09 0.99 -4.17 1.54e-02 3.84e-39 3.22e-01 3.02e-05 1e+00 3.29e-35 1e+00 2.54e-01 PDF
ENSG00000211790 TRAV8-4 3.33 5.81 0.22 -2.79 8.67e-04 6.24e-09 8.25e-01 5.21e-03 1e+00 5.26e-05 1e+00 1e+00 PDF
ENSG00000211794 TRAV12-3 4.59 3.26 -1.6 -5.01 4.35e-06 1.12e-03 1.1e-01 5.44e-07 3.66e-02 1e+00 1e+00 4.62e-03 PDF
ENSG00000211795 TRAV8-6 -2.67 -4.63 -2.95 -2.97 7.66e-03 3.69e-06 3.18e-03 3e-03 1e+00 3.07e-02 1e+00 1e+00 PDF
ENSG00000211796 TRAV16 -5.56 -2.23 -0.26 -2.65 2.73e-08 2.56e-02 7.92e-01 8.03e-03 2.32e-04 1e+00 1e+00 1e+00 PDF
ENSG00000211801 TRAV21 -6.87 -4.48 -1.76 -5.68 6.57e-12 7.39e-06 7.92e-02 1.35e-08 5.61e-08 6.13e-02 1e+00 1.16e-04 PDF
ENSG00000211809 TRAV27 -3.38 1.93 5.77 -0.78 7.26e-04 5.39e-02 7.93e-09 4.33e-01 1e+00 1e+00 6.75e-05 1e+00 PDF
ENSG00000211810 TRAV29DV5 -8.52 -9.88 1.07 1.42 1.57e-17 4.89e-23 2.87e-01 1.54e-01 1.34e-13 4.18e-19 1e+00 1e+00 PDF
ENSG00000211812 TRAV26-2 -0.54 -6.43 -4.09 -3.89 5.9e-01 1.24e-10 4.31e-05 9.88e-05 1e+00 1.05e-06 3.63e-01 8.27e-01 PDF
ENSG00000211817 TRAV38-2DV8 -7.37 -10.55 -4.69 -2.41 1.66e-13 5.19e-26 2.71e-06 1.6e-02 1.41e-09 4.44e-22 2.3e-02 1e+00 PDF
ENSG00000211820 TRAV41 -3.75 3.11 -4.87 -2.97 1.74e-04 1.85e-03 1.11e-06 2.99e-03 1e+00 1e+00 9.44e-03 1e+00 PDF
ENSG00000211829 TRDC -2.89 5.9 2.29 -3.3 3.79e-03 3.7e-09 2.19e-02 9.77e-04 1e+00 3.12e-05 1e+00 1e+00 PDF
ENSG00000213145 CRIP1 4.38 4.61 2.88 2.14 1.2e-05 3.97e-06 4.04e-03 3.28e-02 1e-01 3.3e-02 1e+00 1e+00 PDF
ENSG00000213203 GIMAP1 -4.12 -6.48 -2.6 -2.46 3.77e-05 9.23e-11 9.28e-03 1.39e-02 3.15e-01 7.82e-07 1e+00 1e+00 PDF
ENSG00000213402 PTPRCAP 1.82 7.86 -0.83 -0.47 6.89e-02 3.92e-15 4.06e-01 6.36e-01 1e+00 3.33e-11 1e+00 1e+00 PDF
ENSG00000213626 LBH -7.63 -7.01 -5.18 -4.51 2.39e-14 2.35e-12 2.25e-07 6.63e-06 2.04e-10 2e-08 1.91e-03 5.6e-02 PDF
ENSG00000215845 TSTD1 -3.7 -4.77 -2.85 -3.66 2.15e-04 1.84e-06 4.35e-03 2.49e-04 1e+00 1.53e-02 1e+00 1e+00 PDF
ENSG00000226067 LINC00623 -4.58 -2.27 -3.81 -3.32 4.68e-06 2.32e-02 1.37e-04 8.87e-04 3.93e-02 1e+00 1e+00 1e+00 PDF
ENSG00000226660 TRBV2 -3.85 7.17 5.93 -1.47 1.19e-04 7.38e-13 3.01e-09 1.43e-01 9.91e-01 6.27e-09 2.56e-05 1e+00 PDF
ENSG00000227507 LTB 13.84 -2.88 -0.16 -2.38 1.47e-43 4e-03 8.74e-01 1.71e-02 1.26e-39 1e+00 1e+00 1e+00 PDF
ENSG00000230099 TRBV5-4 -5.32 -10.66 4.32 -2.12 1.02e-07 1.57e-26 1.57e-05 3.41e-02 8.63e-04 1.34e-22 1.33e-01 1e+00 PDF
ENSG00000231682 LINC01891 -1.77 -7.15 -3.66 -2.89 7.68e-02 8.39e-13 2.53e-04 3.83e-03 1e+00 7.13e-09 1e+00 1e+00 PDF
ENSG00000232869 TRBV29-1 6.83 4.51 5.24 2.21 8.72e-12 6.53e-06 1.63e-07 2.74e-02 7.44e-08 5.42e-02 1.39e-03 1e+00 PDF
ENSG00000235532 LINC00402 -4.62 -6.81 -4.18 -4.03 3.78e-06 9.49e-12 2.9e-05 5.6e-05 3.18e-02 8.05e-08 2.44e-01 4.69e-01 PDF
ENSG00000237541 HLA-DQA2 -0.03 -10.96 NaN -5.12 9.73e-01 6.06e-28 Inf 3.01e-07 1e+00 5.18e-24 Inf 2.56e-03 PDF
ENSG00000237702 TRBV3-1 1.87 1.91 9.39 0.32 6.19e-02 5.63e-02 5.91e-21 7.49e-01 1e+00 1e+00 5.06e-17 1e+00 PDF
ENSG00000240065 PSMB9 -3 -5.14 -4.87 -3.06 2.73e-03 2.71e-07 1.14e-06 2.24e-03 1e+00 2.27e-03 9.67e-03 1e+00 PDF
ENSG00000240972 MIF 5.45 -0.99 3.88 2.51 5.18e-08 3.24e-01 1.06e-04 1.21e-02 4.4e-04 1e+00 8.87e-01 1e+00 PDF
ENSG00000241343 RPL36A 1.55 -4.88 4.02 0.53 1.21e-01 1.08e-06 5.92e-05 5.96e-01 1e+00 9.01e-03 4.97e-01 1e+00 PDF
ENSG00000241657 TRBV11-2 -5.89 7.3 -4.41 -0.07 3.93e-09 2.95e-13 1.03e-05 9.47e-01 3.34e-05 2.51e-09 8.69e-02 1e+00 PDF
ENSG00000242086 MUC20-OT1 -3.47 -5.14 -3.95 -2.33 5.12e-04 2.69e-07 7.81e-05 1.97e-02 1e+00 2.26e-03 6.55e-01 1e+00 PDF
ENSG00000243749 TMEM35B -2.93 -5.59 -4.23 -1.91 3.34e-03 2.22e-08 2.37e-05 5.62e-02 1e+00 1.87e-04 2e-01 1e+00 PDF
ENSG00000243927 MRPS6 -5.66 -6.51 -4.25 -2.74 1.51e-08 7.61e-11 2.17e-05 6.21e-03 1.28e-04 6.45e-07 1.83e-01 1e+00 PDF
ENSG00000244734 HBB -32.28 24.08 11.1 47.87 1.46e-228 3.69e-128 1.25e-28 0e+00 1.26e-224 3.17e-124 1.07e-24 0e+00 PDF
ENSG00000245532 NEAT1 -0.37 -6.87 -1.39 -5.35 7.11e-01 6.27e-12 1.64e-01 8.79e-08 1e+00 5.33e-08 1e+00 7.49e-04 PDF
ENSG00000245904 AC025164.1 -2.36 -5.05 -5.04 -5.56 1.82e-02 4.51e-07 4.64e-07 2.69e-08 1e+00 3.78e-03 3.94e-03 2.29e-04 PDF
ENSG00000246223 LINC01550 -2.53 -4.92 -2.73 -3.3 1.13e-02 8.46e-07 6.35e-03 9.69e-04 1e+00 7.07e-03 1e+00 1e+00 PDF
ENSG00000250303 AP002884.1 4.95 2.63 0.41 1.37 7.48e-07 8.56e-03 6.8e-01 1.72e-01 6.32e-03 1e+00 1e+00 1e+00 PDF
ENSG00000253738 OTUD6B-AS1 -4.03 -3.81 -3.11 -4.92 5.5e-05 1.37e-04 1.87e-03 8.51e-07 4.58e-01 1e+00 1e+00 7.22e-03 PDF
ENSG00000254999 BRK1 -1.5 0.19 -1 -5.07 1.35e-01 8.46e-01 3.15e-01 4e-07 1e+00 1e+00 1e+00 3.4e-03 PDF
ENSG00000260708 AL118516.1 2.48 1.07 6.83 6.42 1.31e-02 2.86e-01 8.51e-12 1.36e-10 1e+00 1e+00 7.27e-08 1.17e-06 PDF
ENSG00000268027 AC243960.1 -5.06 -5.74 -4.39 -4.33 4.2e-07 9.55e-09 1.15e-05 1.48e-05 3.55e-03 8.06e-05 9.68e-02 1.25e-01 PDF
ENSG00000271109 AC008555.5 -5.3 -3.59 -1.1 -2.93 1.19e-07 3.33e-04 2.7e-01 3.4e-03 1.01e-03 1e+00 1e+00 1e+00 PDF
ENSG00000271503 CCL5 -11.94 -4.69 0.82 -2.47 7.53e-33 2.77e-06 4.14e-01 1.35e-02 6.46e-29 2.31e-02 1e+00 1e+00 PDF
ENSG00000275074 NUDT18 -0.74 -4.87 -3.15 -1.53 4.61e-01 1.11e-06 1.63e-03 1.27e-01 1e+00 9.29e-03 1e+00 1e+00 PDF
ENSG00000275791 TRBV10-3 -9.98 -5.59 -3.83 4.14 1.85e-23 2.27e-08 1.26e-04 3.54e-05 1.59e-19 1.92e-04 1e+00 2.98e-01 PDF
ENSG00000276557 TRBV18 -1.05 6.86 4.59 -4.52 2.93e-01 6.67e-12 4.35e-06 6.27e-06 1e+00 5.66e-08 3.68e-02 5.29e-02 PDF
ENSG00000276953 TRBV12-4 -8.8 9.42 -4.52 4.24 1.43e-18 4.66e-21 6.16e-06 2.2e-05 1.22e-14 3.98e-17 5.21e-02 1.85e-01 PDF
ENSG00000277734 TRAC -5.32 -1.76 -5.36 -4.53 1.06e-07 7.77e-02 8.29e-08 5.82e-06 9.02e-04 1e+00 7.05e-04 4.92e-02 PDF
ENSG00000278030 TRBV7-9 -2.46 2.45 -10.67 -8.34 1.37e-02 1.44e-02 1.48e-26 7.17e-17 1e+00 1e+00 1.27e-22 6.15e-13 PDF
ENSG00000280721 LINC01943 1.27 6.08 0 1.7 2.03e-01 1.22e-09 1e+00 8.95e-02 1e+00 1.04e-05 1e+00 1e+00 PDF
ENSG00000282939 TRBV7-2 -9.47 9.7 -0.18 3.93 2.67e-21 2.96e-22 8.56e-01 8.59e-05 2.29e-17 2.53e-18 1e+00 7.19e-01 PDF
ENSG00000283782 AC116366.3 -2.44 -4.79 -1.53 -0.1 1.47e-02 1.64e-06 1.25e-01 9.2e-01 1e+00 1.37e-02 1e+00 1e+00 PDF
ENSG00000285437 POLR2J3 -2.04 -2.53 -4.77 -4.38 4.09e-02 1.13e-02 1.84e-06 1.21e-05 1e+00 1e+00 1.56e-02 1.02e-01 PDF
HLA-DR -5.91 -113.34 -1.58 -43.52 3.5e-09 0e+00 1.14e-01 0e+00 2.98e-05 0e+00 1e+00 0e+00 PDF
TIGIT -2.85 -27.33 -3.25 -12.95 4.36e-03 1.83e-164 1.14e-03 2.28e-38 1e+00 1.57e-160 1e+00 1.96e-34 PDF

3. Additional genes/proteins

ensembl_gene_id hgnc_symbol z_mTconv z_mTreg z_nTconv z_nTreg pv_mTconv pv_mTreg pv_nTconv pv_nTreg fwer_mTconv fwer_mTreg fwer_nTconv fwer_nTreg .link
CD27 -63.24 -109.66 -74.51 -117.27 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 0e+00 PDF
CD279 11.18 11.84 0.22 -3.49 4.93e-29 2.5e-32 8.28e-01 4.75e-04 4.23e-25 2.14e-28 1e+00 1e+00 PDF
CD366 4.6 23.15 1.87 -1.62 4.29e-06 1.38e-118 6.12e-02 1.06e-01 3.61e-02 1.18e-114 1e+00 1e+00 PDF
ENSG00000009790 TRAF3IP3 -7.63 -9.81 -7.71 -8.98 2.31e-14 9.9e-23 1.22e-14 2.67e-19 1.98e-10 8.46e-19 1.04e-10 2.29e-15 PDF
ENSG00000049768 FOXP3 -0.41 1.33 -4.35 -0.96 6.85e-01 1.82e-01 1.39e-05 3.37e-01 1e+00 1e+00 1.17e-01 1e+00 PDF
ENSG00000089692 LAG3 2.17 7.43 -0.39 0 3.02e-02 1.07e-13 6.95e-01 1e+00 1e+00 9.1e-10 1e+00 1e+00 PDF
ENSG00000118515 SGK1 3.54 3.64 4.32 0.42 3.94e-04 2.69e-04 1.55e-05 6.73e-01 1e+00 1e+00 1.3e-01 1e+00 PDF
ENSG00000139193 CD27 -3.44 -0.93 -1.18 -3.63 5.85e-04 3.53e-01 2.38e-01 2.85e-04 1e+00 1e+00 1e+00 1e+00 PDF
ENSG00000178562 CD28 -0.83 -3.21 -3.46 -0.59 4.06e-01 1.32e-03 5.38e-04 5.58e-01 1e+00 1e+00 1e+00 1e+00 PDF
ENSG00000188389 PDCD1 4.61 0.3 NaN 0.09 3.96e-06 7.61e-01 Inf 9.29e-01 3.33e-02 1e+00 Inf 1e+00 PDF
ENSG00000198846 TOX 2.06 3.56 2.81 -0.96 3.97e-02 3.65e-04 4.97e-03 3.39e-01 1e+00 1e+00 1e+00 1e+00 PDF

4. Differential Expression Analysis for PRDM1-short vs. long

.data.file <- "data/PRDM1/PRDM1_SL.csv.gz"

.data <-
    fread(.data.file) %>%
    mutate(tag = `CB+batch`) %>%
    parse.tag() %>%
    select(PRDM1_short, PRDM1_long, barcode, batch) %>% 
    left_join(final.cell.type) %>%
    na.omit()

prdm1.aggregate <- 
    rbind(
        dcast(.data,
              subject + disease ~ celltype,
              fun.aggregate = function(x) mean(log1p(x)),
              value.var = "PRDM1_short") %>%
        melt(id.vars = c("subject", "disease")) %>%
        mutate(type="short"),
        dcast(.data,
              subject + disease ~ celltype,
              fun.aggregate = function(x) mean(log1p(x)),
              value.var = "PRDM1_long") %>%
        melt(id.vars = c("subject","disease")) %>%
        mutate(type="long")
    )
.gg.plot(prdm1.aggregate, aes(disease, value, group = disease, fill = disease)) +
    facet_grid(type~variable, scales="free") +
    geom_boxplot(linewidth=.1) +
    geom_jitter(position = position_jitter(w = 0.1, h = 0), stroke = 0) +
    ylab("average expression (log1p)") +
    xlab("disease status") +
    scale_fill_brewer("disease", palette = "Set2")

.gg.plot(prdm1.aggregate, aes(type, value, group = type, fill = type)) +
    facet_grid(disease~variable, scales="free") +
    geom_boxplot(linewidth=.1) +
    geom_jitter(position = position_jitter(w = 0.1, h = 0), stroke = 0) +
    ylab("average expression (log1p)") +
    xlab("disease status") +
    scale_fill_brewer("isoform", palette = "Set3")