Counterfactual Confounder Adjustment for Single-cell Differential Expression Analysis
Yongjin Park
Cell type annotation
Broad cell types
Basic statistics for cell type annotation
- 1,444 cells per individual: 50.65% (N=726 \(\pm\) 382) cells for excitatory neurons, 12.71% (N=182 \(\pm\) 107) cells for inhibitory neurons, 25.72% (N=380 \(\pm\) 252) cells for oligodendrocytes, 2.43% (N= 33 \(\pm\) 24) cells for microglia, 3.56% (N= 54 \(\pm\) 34) cells for oligodendrocyte progenitor cells, 4.94% (N= 69 \(\pm\) 46) cells for astrocytes, 0.1% (N= 2 \(\pm\) 1) cells for pericytes / endothelial cells on average.
The cortical layers of excitatory neurons
- 726 cells per individual: 8.26% (N= 50 \(\pm\) 28) cells for excitatory neurons (L5/6,CC), 52.62% (N=399 \(\pm\) 250) cells for excitatory neurons (L4), 33.1% (N=233 \(\pm\) 108) cells for excitatory neurons (L2/3), 6.03% (N= 44 \(\pm\) 31) cells for excitatory neurons (L5/6) on average.
Inhibitory neuron subtypes
- 182 cells per individual: 24.51% (N=43 \(\pm\) 26) cells for inhibitory neurons (SST), 32.9% (N=59 \(\pm\) 34) cells for inhibitory neurons (VIP), 31.72% (N=59 \(\pm\) 40) cells for inhibitory neurons (PV), 11.1% (N=22 \(\pm\) 17) cells for inhibitory neurons (SV2C) on average.
Differentially Expressed Genes
Association results
The number of genes associated with PathoAD by non-parametric ranksum test
DEGs with FDR controlled at 1%: 1,648 genes (11.68%) consist of 80 found in Astro, 522 found in Ex-L2or3, 672 found in Ex-L4, 297 found in Ex-L5or6, 210 found in In-PV, 11 found in In-SST, 57 found in In-VIP, 84 found in Microglia, 49 found in OPC, 98 found in Oligo, 4 found in In-SV2C
DEGs with FWER controlled at 1%: 215 genes (1.52%) consist of 19 found in Astro, 39 found in Ex-L2or3, 55 found in Ex-L4, 28 found in Ex-L5or6, 24 found in In-PV, 3 found in In-SST, 7 found in In-VIP, 19 found in Microglia, 9 found in OPC, 28 found in Oligo
14,106 genes in total.
Check: Will CoCoA manipulate variance asymmetrically?
## Warning in regularize.values(x, y, ties, missing(ties)): collapsing to unique
## 'x' values
## Warning in regularize.values(x, y, ties, missing(ties)): collapsing to unique
## 'x' values
Check: Can confounding factors associate with biological variables?
## Warning: Removed 19 rows containing non-finite values (stat_binhex).## Warning: Removed 1 rows containing missing values (geom_hex).## Warning: Removed 29959 rows containing non-finite values (stat_binhex).## Warning: Removed 1 rows containing missing values (geom_hex).
The number of genes identified by significant average disease effect (ADE) (local FSR 5%) and non-parametric rank test (Wilcoxon FDR 5%): 4,437
The number of genes identified by significant average disease effect (ADE) (local FSR 1%) and non-parametric rank test (Wilcoxon FDR 1%): 2,316
Show top genes for each cell type and phenotype
## Joining, by = "ct"Controlling Wilcoxon FDR 1% and local FSR 1%, we identified 1,669 gene and cell type pairs, 1,330 AD genes.
- Average: 151.73 \(\pm\) 206.04
A genomic view combining all the cell types, highlighting 289 gene-cell-type pairs and 182 genes (at most top 20 genes per cell type).
## Joining, by = "hgnc_symbol"## Joining, by = c("gene", "celltype")
## Joining, by = c("gene", "celltype")
| pheno | gene | celltype | ADE | lfdr | lfsr | p-value | file |
|---|---|---|---|---|---|---|---|
| pathoAD | AAK1 | excitatory neurons (L2/3) | 0.09 9.6e-03 | 1.0e-17 | 1.3e-17 | 3.2e-05 | |
| pathoAD | AAK1 | excitatory neurons (L5/6) | 0.11 2.0e-02 | 3.6e-06 | 4.3e-06 | 8.5e-08 | |
| pathoAD | ABHD2 | excitatory neurons (L2/3) | 0.12 1.4e-02 | 5.8e-16 | 8.4e-16 | 1.4e-07 | |
| pathoAD | ABHD2 | excitatory neurons (L4) | 0.05 1.1e-02 | 8.0e-07 | 1.3e-06 | 4.8e-04 | |
| pathoAD | ABI1 | astrocytes | -0.15 2.8e-02 | 1.3e-05 | 1.4e-05 | 1.4e-06 | |
| pathoAD | ABLIM1 | excitatory neurons (L2/3) | -0.04 1.1e-02 | 2.3e-04 | 4.1e-04 | 2.8e-05 | |
| pathoAD | AKAP9 | excitatory neurons (L2/3) | 0.11 1.0e-02 | 3.8e-23 | 4.9e-23 | 1.8e-07 | |
| pathoAD | AKAP9 | excitatory neurons (L4) | 0.08 6.9e-03 | 3.5e-31 | 4.1e-31 | 3.6e-08 | |
| pathoAD | AKAP9 | excitatory neurons (L5/6) | 0.15 1.9e-02 | 5.8e-12 | 6.6e-12 | 1.1e-10 | |
| pathoAD | ALK | oligodendrocyte progenitor cells | 0.15 2.0e-02 | 6.2e-11 | 6.7e-11 | 6.1e-07 | |
| pathoAD | ANK2 | oligodendrocytes | -0.1 8.2e-03 | 5.6e-33 | 0.0e+00 | 2.7e-08 | |
| pathoAD | ANKS1B | excitatory neurons (L2/3) | -0.04 4.3e-03 | 1.3e-17 | 0.0e+00 | 2.3e-05 | |
| pathoAD | ANKS1B | oligodendrocytes | -0.1 9.2e-03 | 6.2e-24 | 1.1e-16 | 3.6e-08 | |
| pathoAD | APLP1 | excitatory neurons (L2/3) | 0.08 9.6e-03 | 6.7e-14 | 9.0e-14 | 4.9e-08 | |
| pathoAD | APLP1 | excitatory neurons (L4) | 0.05 6.7e-03 | 4.9e-11 | 6.5e-11 | 2.5e-04 | |
| pathoAD | APOE | microglia | 0.15 2.9e-02 | 9.1e-06 | 9.4e-06 | 2.7e-06 | |
| pathoAD | ARHGAP15 | microglia | 0.23 2.8e-02 | 2.9e-13 | 3.0e-13 | 9.4e-07 | |
| pathoAD | ARHGAP21 | excitatory neurons (L5/6) | -0.11 2.4e-02 | 1.3e-04 | 1.6e-04 | 2.2e-04 | |
| pathoAD | ARHGAP21 | oligodendrocyte progenitor cells | -0.12 2.4e-02 | 3.5e-05 | 3.9e-05 | 4.8e-06 | |
| pathoAD | ATP1A3 | excitatory neurons (L2/3) | 0.08 1.6e-02 | 1.6e-06 | 2.9e-06 | 1.3e-04 | |
| pathoAD | ATP1A3 | inhibitory neurons (VIP) | 0.12 3.2e-02 | 8.0e-03 | 9.9e-03 | 9.9e-06 | |
| pathoAD | ATP2B1 | excitatory neurons (L2/3) | 0.04 5.6e-03 | 7.5e-10 | 9.3e-10 | 8.5e-08 | |
| pathoAD | ATXN2 | astrocytes | -0.13 2.6e-02 | 5.2e-05 | 5.7e-05 | 2.7e-06 | |
| pathoAD | ATXN2 | inhibitory neurons (PV) | -0.12 2.2e-02 | 3.6e-06 | 4.3e-06 | 7.6e-07 | |
| pathoAD | BAIAP2 | excitatory neurons (L5/6) | 0.12 2.3e-02 | 1.9e-05 | 2.4e-05 | 1.4e-07 | |
| pathoAD | BCAS3 | astrocytes | -0.18 2.2e-02 | 1.9e-12 | 2.0e-12 | 2.4e-07 | |
| pathoAD | BLNK | microglia | 0.16 4.1e-02 | 2.3e-03 | 2.4e-03 | 3.2e-06 | |
| pathoAD | C10orf90 | oligodendrocytes | 0.07 8.8e-03 | 1.1e-14 | 1.2e-14 | 1.4e-08 | |
| pathoAD | C2CD5 | inhibitory neurons (PV) | -0.11 2.2e-02 | 6.9e-05 | 8.4e-05 | 2.4e-07 | |
| pathoAD | CACNA1E | excitatory neurons (L4) | 0.07 8.4e-03 | 1.8e-16 | 2.3e-16 | 1.0e-09 | |
| pathoAD | CADM1 | oligodendrocyte progenitor cells | 0.09 1.8e-02 | 1.3e-05 | 1.4e-05 | 3.8e-07 | |
| pathoAD | CALM1 | excitatory neurons (L5/6) | 0.06 1.1e-02 | 1.3e-07 | 1.4e-07 | 2.5e-04 | |
| pathoAD | CALM1 | inhibitory neurons (PV) | 0.06 1.2e-02 | 4.9e-06 | 5.5e-06 | 6.9e-06 | |
| pathoAD | CALM1 | inhibitory neurons (SV2C) | 0.2 2.3e-02 | 8.5e-15 | 8.8e-15 | 3.2e-06 | |
| pathoAD | CALM1 | inhibitory neurons (VIP) | 0.11 1.5e-02 | 2.2e-11 | 2.3e-11 | 1.1e-07 | |
| pathoAD | CAMSAP2 | inhibitory neurons (PV) | 0.07 2.1e-02 | 2.8e-03 | 3.6e-03 | 1.8e-07 | |
| pathoAD | CCDC146 | excitatory neurons (L4) | 0.06 1.6e-02 | 2.1e-04 | 4.7e-04 | 1.2e-05 | |
| pathoAD | CCDC146 | oligodendrocyte progenitor cells | 0.14 3.3e-02 | 1.5e-03 | 1.8e-03 | 8.3e-06 | |
| pathoAD | CDH20 | oligodendrocytes | 0.07 8.6e-03 | 1.6e-15 | 1.7e-15 | 1.8e-07 | |
| pathoAD | CELF2 | oligodendrocyte progenitor cells | -0.14 2.6e-02 | 5.3e-06 | 6.0e-06 | 9.9e-06 | |
| pathoAD | CHL1 | oligodendrocyte progenitor cells | 0.06 1.5e-02 | 2.5e-04 | 2.7e-04 | 9.9e-06 | |
| pathoAD | CLASP2 | astrocytes | -0.1 2.0e-02 | 3.8e-05 | 4.1e-05 | 2.2e-06 | |
| pathoAD | CLASP2 | excitatory neurons (L2/3) | -0.06 7.6e-03 | 6.9e-16 | 7.8e-16 | 7.0e-05 | |
| pathoAD | CLASP2 | excitatory neurons (L4) | -0.07 5.3e-03 | 4.3e-34 | 1.1e-16 | 2.7e-08 | |
| pathoAD | CNRIP1 | excitatory neurons (L4) | 0.05 1.1e-02 | 1.6e-05 | 2.9e-05 | 8.3e-06 | |
| pathoAD | CNTN1 | astrocytes | 0.11 1.7e-02 | 3.6e-08 | 3.8e-08 | 9.4e-07 | |
| pathoAD | CNTN1 | oligodendrocyte progenitor cells | -0.1 1.5e-02 | 1.9e-08 | 2.0e-08 | 1.2e-05 | |
| pathoAD | COBL | oligodendrocytes | -0.09 1.1e-02 | 6.2e-14 | 6.7e-14 | 7.4e-09 | |
| pathoAD | COX7C | inhibitory neurons (VIP) | 0.19 3.3e-02 | 7.0e-05 | 8.3e-05 | 5.8e-06 | |
| pathoAD | CPE | astrocytes | 0.08 1.3e-02 | 3.5e-08 | 3.6e-08 | 2.4e-07 | |
| pathoAD | CPE | excitatory neurons (L2/3) | 0.07 1.1e-02 | 8.4e-10 | 1.2e-09 | 2.8e-05 | |
| pathoAD | CPQ | oligodendrocytes | 0.12 1.4e-02 | 1.0e-14 | 1.1e-14 | 2.0e-08 | |
| pathoAD | CRTC3 | oligodendrocytes | -0.09 1.7e-02 | 6.0e-06 | 7.1e-06 | 2.4e-07 | |
| pathoAD | DCLK1 | excitatory neurons (L2/3) | -0.09 7.1e-03 | 6.5e-33 | 0.0e+00 | 9.4e-07 | |
| pathoAD | DCLK1 | excitatory neurons (L4) | -0.05 4.5e-03 | 1.4e-29 | 0.0e+00 | 3.7e-10 | |
| pathoAD | DDX17 | astrocytes | 0.14 1.9e-02 | 1.2e-10 | 1.2e-10 | 3.6e-08 | |
| pathoAD | DGKI | excitatory neurons (L4) | -0.04 5.7e-03 | 2.3e-12 | 2.9e-12 | 6.0e-05 | |
| pathoAD | DGKI | excitatory neurons (L5/6) | -0.05 1.4e-02 | 1.3e-03 | 1.5e-03 | 2.5e-04 | |
| pathoAD | DGKI | inhibitory neurons (SV2C) | -0.13 3.4e-02 | 5.5e-03 | 6.0e-03 | 2.2e-06 | |
| pathoAD | DLG2 | inhibitory neurons (VIP) | 0.06 9.4e-03 | 8.0e-08 | 8.4e-08 | 5.2e-05 | |
| pathoAD | DLG2 | oligodendrocytes | -0.05 4.8e-03 | 6.7e-24 | 0.0e+00 | 1.4e-08 | |
| pathoAD | DNM3 | inhibitory neurons (VIP) | 0.07 2.0e-02 | 7.2e-03 | 8.5e-03 | 4.8e-06 | |
| pathoAD | DOCK7 | astrocytes | 0.09 2.1e-02 | 8.9e-04 | 9.6e-04 | 7.6e-07 | |
| pathoAD | DPP10 | excitatory neurons (L5/6) | 0.06 7.6e-03 | 1.1e-13 | 1.1e-13 | 1.1e-07 | |
| pathoAD | DSCAM | excitatory neurons (L2/3) | 0.05 6.4e-03 | 6.1e-13 | 7.5e-13 | 7.0e-05 | |
| pathoAD | DSCAM | inhibitory neurons (PV) | -0.36 3.3e-02 | 9.2e-23 | 1.1e-16 | 1.4e-07 | |
| pathoAD | DST | inhibitory neurons (SST) | 0.11 2.5e-02 | 3.0e-03 | 3.1e-03 | 2.2e-06 | |
| pathoAD | DST | oligodendrocytes | 0.07 8.1e-03 | 8.9e-16 | 9.3e-16 | 9.4e-07 | |
| pathoAD | EDIL3 | oligodendrocyte progenitor cells | 0.17 1.9e-02 | 5.8e-15 | 6.1e-15 | 3.8e-07 | |
| pathoAD | ELMO1 | excitatory neurons (L4) | -0.07 8.1e-03 | 8.4e-15 | 1.1e-14 | 2.0e-05 | |
| pathoAD | ELMO1 | inhibitory neurons (PV) | -0.1 2.4e-02 | 4.4e-04 | 5.6e-04 | 2.2e-04 | |
| pathoAD | ELMO1 | oligodendrocyte progenitor cells | -0.18 3.0e-02 | 4.0e-06 | 4.6e-06 | 3.2e-06 | |
| pathoAD | EML6 | excitatory neurons (L2/3) | -0.11 1.1e-02 | 4.3e-23 | 1.1e-16 | 1.1e-07 | |
| pathoAD | EML6 | excitatory neurons (L4) | -0.08 8.3e-03 | 1.2e-20 | 0.0e+00 | 6.9e-06 | |
| pathoAD | EML6 | inhibitory neurons (PV) | -0.1 2.8e-02 | 4.0e-03 | 5.5e-03 | 9.4e-05 | |
| pathoAD | EPB41L3 | inhibitory neurons (PV) | -0.15 1.9e-02 | 1.5e-12 | 1.7e-12 | 8.5e-08 | |
| pathoAD | EPHA5 | excitatory neurons (L5/6) | -0.1 1.9e-02 | 6.1e-06 | 7.3e-06 | 3.8e-05 | |
| pathoAD | EPHB1 | excitatory neurons (L2/3) | -0.11 1.6e-02 | 1.5e-11 | 2.4e-11 | 6.4e-08 | |
| pathoAD | EPHB1 | excitatory neurons (L4) | -0.11 1.3e-02 | 3.7e-15 | 5.6e-15 | 1.8e-06 | |
| pathoAD | EPS15L1 | excitatory neurons (L4) | -0.06 1.2e-02 | 2.6e-07 | 4.4e-07 | 2.2e-04 | |
| pathoAD | EPS15L1 | inhibitory neurons (PV) | -0.13 3.2e-02 | 2.3e-03 | 3.2e-03 | 3.8e-07 | |
| pathoAD | ERBB2IP | astrocytes | 0.14 2.1e-02 | 6.5e-09 | 6.9e-09 | 1.1e-07 | |
| pathoAD | ERBB2IP | excitatory neurons (L4) | -0.06 1.3e-02 | 7.0e-06 | 1.3e-05 | 3.7e-04 | |
| pathoAD | ERBB2IP | oligodendrocytes | 0.09 7.8e-03 | 1.0e-28 | 1.1e-28 | 4.8e-06 | |
| pathoAD | ETV6 | microglia | 0.23 3.5e-02 | 1.1e-08 | 1.1e-08 | 3.8e-07 | |
| pathoAD | EXOC6B | excitatory neurons (L5/6) | -0.08 1.8e-02 | 5.8e-05 | 7.0e-05 | 3.8e-07 | |
| pathoAD | FAIM2 | excitatory neurons (L2/3) | 0.07 9.5e-03 | 3.2e-12 | 4.4e-12 | 5.2e-05 | |
| pathoAD | FAIM2 | inhibitory neurons (PV) | 0.08 1.8e-02 | 5.3e-05 | 6.2e-05 | 1.8e-07 | |
| pathoAD | FAM171A1 | excitatory neurons (L5/6) | -0.19 2.7e-02 | 1.3e-08 | 1.5e-08 | 3.8e-07 | |
| pathoAD | FAM171B | excitatory neurons (L2/3) | 0.1 1.4e-02 | 3.9e-10 | 6.2e-10 | 1.2e-05 | |
| pathoAD | FAM171B | excitatory neurons (L4) | 0.07 9.6e-03 | 6.5e-11 | 9.4e-11 | 1.1e-10 | |
| pathoAD | FAM69A | excitatory neurons (L5/6) | -0.11 3.0e-02 | 6.3e-03 | 9.1e-03 | 8.5e-08 | |
| pathoAD | FBXL17 | inhibitory neurons (VIP) | -0.09 2.1e-02 | 1.1e-03 | 1.3e-03 | 1.4e-06 | |
| pathoAD | FCHSD2 | inhibitory neurons (VIP) | -0.15 2.7e-02 | 4.3e-05 | 5.0e-05 | 1.1e-07 | |
| pathoAD | FGD4 | microglia | 0.21 3.4e-02 | 1.2e-07 | 1.2e-07 | 3.2e-06 | |
| pathoAD | FGF12 | inhibitory neurons (PV) | 0.08 8.5e-03 | 8.3e-18 | 8.7e-18 | 3.6e-08 | |
| pathoAD | FIGN | oligodendrocyte progenitor cells | 0.2 2.8e-02 | 2.3e-09 | 2.5e-09 | 7.6e-07 | |
| pathoAD | FNIP2 | excitatory neurons (L2/3) | 0.14 1.4e-02 | 3.9e-21 | 5.3e-21 | 3.6e-08 | |
| pathoAD | FNIP2 | excitatory neurons (L4) | 0.08 9.5e-03 | 2.2e-15 | 3.0e-15 | 4.9e-08 | |
| pathoAD | FSTL4 | excitatory neurons (L4) | -0.07 6.6e-03 | 3.4e-27 | 0.0e+00 | 6.4e-10 | |
| pathoAD | FUT8 | excitatory neurons (L2/3) | -0.06 1.6e-02 | 1.0e-04 | 2.0e-04 | 3.7e-04 | |
| pathoAD | FUT8 | excitatory neurons (L4) | -0.05 9.1e-03 | 4.5e-07 | 6.8e-07 | 3.8e-05 | |
| pathoAD | FUT8 | excitatory neurons (L5/6) | -0.14 2.9e-02 | 2.6e-04 | 3.4e-04 | 6.1e-07 | |
| pathoAD | FUT8 | oligodendrocytes | -0.11 1.0e-02 | 2.3e-22 | 1.1e-16 | 2.0e-08 | |
| pathoAD | GABRA1 | inhibitory neurons (PV) | 0.09 1.6e-02 | 1.7e-06 | 1.9e-06 | 2.0e-08 | |
| pathoAD | GHITM | excitatory neurons (L2/3) | 0.08 1.7e-02 | 1.6e-05 | 3.2e-05 | 1.0e-08 | |
| pathoAD | GNAS | excitatory neurons (L2/3) | 0.05 9.2e-03 | 2.2e-08 | 3.2e-08 | 2.2e-04 | |
| pathoAD | GPHN | excitatory neurons (L2/3) | -0.03 6.9e-03 | 1.9e-05 | 2.7e-05 | 9.4e-05 | |
| pathoAD | GPHN | excitatory neurons (L4) | -0.05 4.7e-03 | 4.7e-28 | 0.0e+00 | 2.4e-07 | |
| pathoAD | GPHN | excitatory neurons (L5/6) | -0.11 1.5e-02 | 8.3e-12 | 9.2e-12 | 1.4e-07 | |
| pathoAD | GPHN | inhibitory neurons (PV) | -0.13 1.2e-02 | 9.0e-22 | 0.0e+00 | 7.6e-07 | |
| pathoAD | GPM6A | excitatory neurons (L2/3) | 0.03 5.3e-03 | 5.5e-07 | 7.0e-07 | 1.7e-05 | |
| pathoAD | GPM6A | excitatory neurons (L4) | 0.04 3.8e-03 | 4.8e-23 | 5.3e-23 | 9.4e-07 | |
| pathoAD | GPM6A | inhibitory neurons (VIP) | 0.1 1.7e-02 | 7.4e-07 | 8.1e-07 | 1.8e-07 | |
| pathoAD | GRM5 | oligodendrocyte progenitor cells | 0.15 1.9e-02 | 4.7e-13 | 5.0e-13 | 4.9e-08 | |
| pathoAD | HDAC9 | excitatory neurons (L4) | -0.06 7.4e-03 | 8.9e-17 | 1.1e-16 | 3.2e-05 | |
| pathoAD | HDAC9 | microglia | 0.17 2.7e-02 | 3.0e-08 | 3.1e-08 | 2.4e-07 | |
| pathoAD | HECTD4 | excitatory neurons (L2/3) | -0.09 1.0e-02 | 6.4e-16 | 1.0e-15 | 2.7e-06 | |
| pathoAD | HIBCH | excitatory neurons (L2/3) | 0.08 1.7e-02 | 2.5e-05 | 5.1e-05 | 4.2e-04 | |
| pathoAD | HIBCH | excitatory neurons (L4) | 0.06 1.1e-02 | 7.4e-07 | 1.2e-06 | 2.2e-04 | |
| pathoAD | HIBCH | excitatory neurons (L5/6) | 0.13 3.1e-02 | 9.0e-04 | 1.2e-03 | 3.0e-07 | |
| pathoAD | HLF | excitatory neurons (L2/3) | 0.08 1.5e-02 | 3.5e-06 | 6.3e-06 | 2.9e-04 | |
| pathoAD | HLF | excitatory neurons (L4) | 0.11 1.0e-02 | 1.0e-24 | 1.3e-24 | 2.7e-08 | |
| pathoAD | HNRNPA2B1 | astrocytes | 0.13 3.4e-02 | 6.4e-03 | 7.2e-03 | 9.9e-06 | |
| pathoAD | HNRNPA2B1 | oligodendrocyte progenitor cells | 0.15 3.2e-02 | 3.7e-04 | 4.4e-04 | 6.1e-07 | |
| pathoAD | HSP90AB1 | excitatory neurons (L2/3) | 0.05 8.0e-03 | 9.5e-10 | 1.3e-09 | 5.8e-06 | |
| pathoAD | HSP90AB1 | inhibitory neurons (PV) | 0.09 1.4e-02 | 2.5e-09 | 2.7e-09 | 6.0e-05 | |
| pathoAD | ICA1L | excitatory neurons (L4) | -0.04 8.4e-03 | 1.2e-06 | 1.8e-06 | 4.8e-04 | |
| pathoAD | IDS | excitatory neurons (L2/3) | 0.14 9.8e-03 | 1.8e-42 | 2.1e-42 | 3.8e-07 | |
| pathoAD | IGFBP7 | astrocytes | 0.13 2.9e-02 | 2.5e-04 | 2.7e-04 | 1.1e-07 | |
| pathoAD | IL1RAP | excitatory neurons (L4) | -0.11 1.7e-02 | 2.0e-09 | 3.6e-09 | 4.9e-08 | |
| pathoAD | IMMP2L | inhibitory neurons (VIP) | -0.11 2.4e-02 | 4.9e-04 | 5.7e-04 | 4.8e-06 | |
| pathoAD | IQSEC1 | inhibitory neurons (PV) | -0.11 2.5e-02 | 1.1e-04 | 1.4e-04 | 4.8e-07 | |
| pathoAD | ITM2B | excitatory neurons (L2/3) | 0.14 1.2e-02 | 6.2e-28 | 8.0e-28 | 6.4e-08 | |
| pathoAD | ITM2B | excitatory neurons (L4) | 0.08 7.0e-03 | 7.8e-32 | 9.3e-32 | 1.8e-07 | |
| pathoAD | ITM2B | inhibitory neurons (VIP) | 0.16 2.7e-02 | 4.4e-06 | 5.0e-06 | 1.4e-05 | |
| pathoAD | JARID2 | astrocytes | -0.19 2.5e-02 | 1.5e-10 | 1.6e-10 | 3.8e-07 | |
| pathoAD | JPH4 | excitatory neurons (L2/3) | 0.14 1.1e-02 | 1.7e-33 | 2.1e-33 | 1.8e-06 | |
| pathoAD | JPH4 | excitatory neurons (L4) | 0.11 8.4e-03 | 2.5e-35 | 3.0e-35 | 1.0e-08 | |
| pathoAD | KCNH8 | oligodendrocytes | -0.1 9.2e-03 | 1.9e-24 | 0.0e+00 | 2.4e-09 | |
| pathoAD | KCNIP4 | inhibitory neurons (SST) | -0.09 1.6e-02 | 5.2e-06 | 5.4e-06 | 9.4e-07 | |
| pathoAD | KCNMA1 | excitatory neurons (L2/3) | -0.05 6.3e-03 | 1.2e-14 | 1.4e-14 | 1.0e-09 | |
| pathoAD | KCNMA1 | excitatory neurons (L4) | -0.03 4.7e-03 | 3.9e-11 | 4.8e-11 | 4.8e-04 | |
| pathoAD | KIF13A | oligodendrocytes | -0.09 1.2e-02 | 2.8e-12 | 3.1e-12 | 1.1e-07 | |
| pathoAD | KIF1B | excitatory neurons (L4) | -0.06 5.9e-03 | 6.2e-20 | 0.0e+00 | 6.4e-08 | |
| pathoAD | KLF12 | oligodendrocyte progenitor cells | 0.07 1.9e-02 | 2.6e-03 | 2.9e-03 | 9.4e-07 | |
| pathoAD | KMT2C | astrocytes | -0.15 2.4e-02 | 1.1e-07 | 1.1e-07 | 1.4e-07 | |
| pathoAD | LARGE | excitatory neurons (L2/3) | 0.06 9.0e-03 | 7.0e-10 | 9.7e-10 | 8.2e-05 | |
| pathoAD | LARGE | excitatory neurons (L5/6) | -0.08 1.6e-02 | 4.9e-06 | 5.7e-06 | 2.9e-04 | |
| pathoAD | LARGE | inhibitory neurons (PV) | -0.13 1.7e-02 | 8.6e-11 | 9.6e-11 | 6.1e-07 | |
| pathoAD | LHFPL2 | microglia | 0.27 3.5e-02 | 2.1e-11 | 2.1e-11 | 8.5e-08 | |
| pathoAD | LRP1B | inhibitory neurons (PV) | 0.15 1.0e-02 | 7.6e-47 | 7.9e-47 | 2.4e-09 | |
| pathoAD | LRP1B | inhibitory neurons (VIP) | 0.06 9.7e-03 | 2.6e-09 | 2.7e-09 | 6.0e-05 | |
| pathoAD | MARK3 | astrocytes | -0.18 2.5e-02 | 2.1e-09 | 2.2e-09 | 2.4e-07 | |
| pathoAD | MARK3 | excitatory neurons (L2/3) | -0.06 1.1e-02 | 8.8e-08 | 1.4e-07 | 8.3e-06 | |
| pathoAD | MARK3 | excitatory neurons (L4) | -0.04 8.2e-03 | 1.6e-05 | 2.4e-05 | 1.9e-04 | |
| pathoAD | MARK3 | excitatory neurons (L5/6) | -0.12 2.5e-02 | 8.4e-05 | 1.1e-04 | 6.0e-05 | |
| pathoAD | MARK3 | inhibitory neurons (PV) | -0.09 2.4e-02 | 1.4e-03 | 1.8e-03 | 1.2e-05 | |
| pathoAD | MARK3 | oligodendrocytes | -0.06 1.7e-02 | 4.8e-03 | 6.0e-03 | 3.2e-05 | |
| pathoAD | MBD5 | astrocytes | -0.1 2.1e-02 | 1.2e-04 | 1.3e-04 | 2.8e-05 | |
| pathoAD | MBD5 | excitatory neurons (L2/3) | 0.06 8.0e-03 | 1.6e-12 | 2.0e-12 | 1.4e-07 | |
| pathoAD | MBNL1 | microglia | 0.15 2.8e-02 | 1.1e-05 | 1.1e-05 | 6.1e-07 | |
| pathoAD | MTUS2 | excitatory neurons (L4) | 0.05 5.9e-03 | 1.3e-18 | 1.5e-18 | 2.0e-05 | |
| pathoAD | MTUS2 | inhibitory neurons (VIP) | 0.09 1.8e-02 | 1.2e-05 | 1.3e-05 | 2.4e-07 | |
| pathoAD | MYH10 | excitatory neurons (L5/6) | -0.14 2.4e-02 | 3.0e-07 | 3.6e-07 | 4.9e-08 | |
| pathoAD | NBEAL1 | excitatory neurons (L4) | 0.06 1.0e-02 | 1.3e-09 | 2.0e-09 | 3.6e-08 | |
| pathoAD | NCAM1 | astrocytes | 0.07 1.7e-02 | 1.8e-03 | 1.9e-03 | 1.1e-04 | |
| pathoAD | NCAM1 | oligodendrocyte progenitor cells | 0.08 1.5e-02 | 4.6e-06 | 5.0e-06 | 2.2e-06 | |
| pathoAD | NCAM1 | oligodendrocytes | 0.04 7.2e-03 | 1.6e-06 | 1.7e-06 | 1.4e-06 | |
| pathoAD | NCAM2 | excitatory neurons (L4) | 0.08 5.4e-03 | 1.9e-44 | 2.1e-44 | 1.1e-10 | |
| pathoAD | NCOA7 | excitatory neurons (L2/3) | 0.09 1.2e-02 | 2.1e-12 | 3.1e-12 | 1.1e-07 | |
| pathoAD | NCOA7 | excitatory neurons (L4) | 0.06 7.7e-03 | 6.9e-16 | 8.8e-16 | 3.6e-09 | |
| pathoAD | NCOA7 | excitatory neurons (L5/6) | 0.14 2.4e-02 | 7.5e-07 | 9.1e-07 | 1.4e-05 | |
| pathoAD | NEBL | astrocytes | 0.14 1.3e-02 | 1.7e-22 | 1.8e-22 | 2.4e-09 | |
| pathoAD | NEBL | inhibitory neurons (VIP) | -0.08 2.1e-02 | 4.8e-03 | 5.6e-03 | 5.8e-06 | |
| pathoAD | NEGR1 | excitatory neurons (L2/3) | 0.04 5.0e-03 | 4.2e-18 | 4.8e-18 | 1.5e-04 | |
| pathoAD | NEGR1 | oligodendrocyte progenitor cells | 0.08 1.9e-02 | 6.6e-04 | 7.4e-04 | 6.1e-07 | |
| pathoAD | NLGN1 | inhibitory neurons (SST) | -0.11 1.8e-02 | 2.8e-07 | 2.9e-07 | 8.3e-06 | |
| pathoAD | NLGN1 | oligodendrocyte progenitor cells | 0.07 9.3e-03 | 2.5e-13 | 2.6e-13 | 3.2e-05 | |
| pathoAD | NLGN1 | oligodendrocytes | -0.06 7.9e-03 | 4.4e-13 | 4.6e-13 | 5.1e-09 | |
| pathoAD | NMT1 | excitatory neurons (L2/3) | 0.09 1.5e-02 | 1.8e-08 | 3.0e-08 | 1.0e-08 | |
| pathoAD | OTUD7B | oligodendrocytes | 0.09 1.6e-02 | 1.9e-06 | 2.1e-06 | 2.4e-07 | |
| pathoAD | PCDH11X | inhibitory neurons (VIP) | -0.13 2.2e-02 | 3.3e-06 | 3.7e-06 | 3.2e-06 | |
| pathoAD | PCDH17 | excitatory neurons (L5/6) | -0.15 2.5e-02 | 1.3e-06 | 1.6e-06 | 2.4e-07 | |
| pathoAD | PCNX | excitatory neurons (L5/6) | -0.18 2.9e-02 | 6.0e-07 | 7.5e-07 | 3.6e-08 | |
| pathoAD | PCSK1N | excitatory neurons (L2/3) | 0.07 1.0e-02 | 1.4e-12 | 1.9e-12 | 5.2e-05 | |
| pathoAD | PCSK1N | inhibitory neurons (SST) | 0.15 3.1e-02 | 1.3e-03 | 1.4e-03 | 3.8e-07 | |
| pathoAD | PDZD2 | oligodendrocyte progenitor cells | 0.1 1.2e-02 | 7.4e-16 | 7.7e-16 | 3.9e-06 | |
| pathoAD | PDZRN3 | excitatory neurons (L2/3) | 0.08 1.2e-02 | 1.3e-09 | 1.9e-09 | 4.4e-05 | |
| pathoAD | PDZRN3 | excitatory neurons (L4) | 0.07 7.1e-03 | 1.1e-24 | 1.3e-24 | 3.6e-09 | |
| pathoAD | PEX5L | inhibitory neurons (VIP) | 0.12 2.1e-02 | 1.1e-05 | 1.2e-05 | 1.1e-07 | |
| pathoAD | PEX5L | oligodendrocytes | 0.05 7.2e-03 | 3.4e-12 | 3.6e-12 | 6.9e-06 | |
| pathoAD | PKM | excitatory neurons (L2/3) | 0.1 9.3e-03 | 3.3e-23 | 4.1e-23 | 3.6e-09 | |
| pathoAD | PLCB1 | astrocytes | -0.13 1.8e-02 | 6.1e-11 | 6.3e-11 | 9.4e-07 | |
| pathoAD | PLXDC2 | astrocytes | 0.17 4.1e-02 | 2.4e-03 | 2.8e-03 | 1.8e-06 | |
| pathoAD | PLXDC2 | excitatory neurons (L2/3) | 0.08 1.1e-02 | 2.0e-13 | 2.8e-13 | 1.9e-04 | |
| pathoAD | PLXDC2 | excitatory neurons (L4) | 0.06 6.9e-03 | 6.0e-18 | 7.4e-18 | 1.8e-07 | |
| pathoAD | PNISR | excitatory neurons (L2/3) | 0.06 7.4e-03 | 9.3e-14 | 1.2e-13 | 3.0e-07 | |
| pathoAD | PNISR | excitatory neurons (L4) | 0.06 5.6e-03 | 5.7e-22 | 6.8e-22 | 1.8e-07 | |
| pathoAD | PNISR | oligodendrocyte progenitor cells | 0.09 1.9e-02 | 4.6e-05 | 5.1e-05 | 2.8e-05 | |
| pathoAD | PPP1R12B | excitatory neurons (L2/3) | -0.06 1.2e-02 | 3.1e-06 | 5.2e-06 | 2.2e-04 | |
| pathoAD | PPP1R12B | oligodendrocytes | -0.08 1.3e-02 | 2.2e-07 | 2.5e-07 | 1.0e-08 | |
| pathoAD | PRICKLE1 | excitatory neurons (L4) | 0.04 7.3e-03 | 5.8e-08 | 8.1e-08 | 2.9e-04 | |
| pathoAD | PRICKLE1 | excitatory neurons (L5/6) | -0.13 2.2e-02 | 7.6e-07 | 9.1e-07 | 3.0e-07 | |
| pathoAD | PRICKLE2 | inhibitory neurons (PV) | -0.16 2.3e-02 | 6.1e-09 | 7.2e-09 | 1.8e-07 | |
| pathoAD | PRKAR1B | excitatory neurons (L5/6) | 0.09 2.2e-02 | 3.8e-04 | 4.9e-04 | 4.9e-08 | |
| pathoAD | PSAP | excitatory neurons (L4) | 0.04 5.7e-03 | 3.9e-11 | 4.9e-11 | 9.9e-06 | |
| pathoAD | PSAP | excitatory neurons (L5/6) | 0.1 1.8e-02 | 6.2e-07 | 7.3e-07 | 1.1e-07 | |
| pathoAD | PTN | astrocytes | -0.13 2.0e-02 | 1.4e-09 | 1.5e-09 | 2.4e-07 | |
| pathoAD | PTPRA | excitatory neurons (L4) | 0.06 7.8e-03 | 1.1e-12 | 1.5e-12 | 1.4e-08 | |
| pathoAD | PTPRJ | excitatory neurons (L2/3) | -0.12 1.8e-02 | 1.6e-10 | 2.7e-10 | 2.3e-05 | |
| pathoAD | PTPRJ | microglia | 0.26 3.3e-02 | 1.1e-11 | 1.1e-11 | 6.9e-06 | |
| pathoAD | RAD51B | oligodendrocytes | -0.11 1.5e-02 | 2.5e-09 | 2.8e-09 | 1.4e-07 | |
| pathoAD | RASGRF2 | excitatory neurons (L2/3) | -0.12 8.6e-03 | 6.2e-45 | 0.0e+00 | 2.7e-08 | |
| pathoAD | RBFOX2 | astrocytes | -0.13 2.7e-02 | 9.1e-05 | 9.9e-05 | 6.9e-06 | |
| pathoAD | RCAN2 | inhibitory neurons (PV) | 0.07 2.0e-02 | 3.1e-03 | 3.9e-03 | 1.9e-04 | |
| pathoAD | RCAN2 | oligodendrocytes | -0.1 1.9e-02 | 8.0e-06 | 9.4e-06 | 2.4e-07 | |
| pathoAD | RELN | inhibitory neurons (VIP) | -0.14 2.3e-02 | 1.9e-06 | 2.1e-06 | 3.9e-06 | |
| pathoAD | RFWD2 | excitatory neurons (L5/6) | -0.17 2.7e-02 | 2.3e-07 | 2.8e-07 | 2.4e-07 | |
| pathoAD | RNF150 | excitatory neurons (L2/3) | 0.11 1.4e-02 | 6.3e-13 | 9.5e-13 | 1.2e-05 | |
| pathoAD | RTN1 | excitatory neurons (L2/3) | 0.09 7.6e-03 | 2.0e-29 | 2.3e-29 | 1.1e-07 | |
| pathoAD | RTN1 | excitatory neurons (L4) | 0.04 4.4e-03 | 1.3e-19 | 1.5e-19 | 3.2e-06 | |
| pathoAD | RTN3 | excitatory neurons (L4) | 0.04 4.6e-03 | 2.2e-15 | 2.6e-15 | 6.9e-06 | |
| pathoAD | RTN3 | inhibitory neurons (PV) | 0.08 1.5e-02 | 1.8e-06 | 2.1e-06 | 6.1e-07 | |
| pathoAD | RUNX1 | microglia | 0.25 3.0e-02 | 1.3e-13 | 1.4e-13 | 3.9e-06 | |
| pathoAD | SARAF | excitatory neurons (L2/3) | 0.09 1.0e-02 | 4.4e-16 | 5.8e-16 | 1.1e-07 | |
| pathoAD | SARAF | excitatory neurons (L4) | 0.07 6.5e-03 | 4.7e-24 | 5.6e-24 | 1.8e-07 | |
| pathoAD | SARAF | oligodendrocytes | 0.07 1.9e-02 | 3.4e-03 | 4.3e-03 | 7.0e-05 | |
| pathoAD | SEPT11 | excitatory neurons (L4) | 0.06 8.4e-03 | 2.1e-12 | 2.9e-12 | 3.6e-08 | |
| pathoAD | SETD5 | inhibitory neurons (PV) | -0.09 2.1e-02 | 1.5e-04 | 1.8e-04 | 4.9e-08 | |
| pathoAD | SH3RF3 | microglia | 0.23 3.4e-02 | 8.0e-09 | 8.3e-09 | 1.4e-07 | |
| pathoAD | SHANK2 | inhibitory neurons (PV) | -0.09 1.9e-02 | 1.2e-05 | 1.4e-05 | 4.9e-08 | |
| pathoAD | SHC3 | excitatory neurons (L5/6) | -0.16 2.8e-02 | 4.1e-06 | 5.2e-06 | 1.1e-07 | |
| pathoAD | SLC1A2 | oligodendrocyte progenitor cells | 0.12 1.9e-02 | 3.8e-08 | 4.1e-08 | 2.2e-06 | |
| pathoAD | SLC4A10 | excitatory neurons (L2/3) | 0.03 6.8e-03 | 1.9e-06 | 2.6e-06 | 1.3e-04 | |
| pathoAD | SLC4A10 | excitatory neurons (L4) | 0.02 5.0e-03 | 1.6e-06 | 2.1e-06 | 3.3e-04 | |
| pathoAD | SLC4A10 | inhibitory neurons (SST) | -0.1 2.4e-02 | 6.9e-03 | 7.4e-03 | 1.2e-06 | |
| pathoAD | SLC6A1 | inhibitory neurons (PV) | 0.1 1.7e-02 | 3.5e-08 | 4.0e-08 | 2.4e-07 | |
| pathoAD | SLC9A9 | microglia | 0.22 2.7e-02 | 4.4e-14 | 4.5e-14 | 1.4e-06 | |
| pathoAD | SLC9A9 | oligodendrocyte progenitor cells | 0.11 2.6e-02 | 1.1e-03 | 1.2e-03 | 6.1e-07 | |
| pathoAD | SLCO1C1 | astrocytes | -0.21 2.7e-02 | 1.1e-11 | 1.2e-11 | 1.4e-08 | |
| pathoAD | SNX3 | excitatory neurons (L2/3) | 0.08 1.4e-02 | 1.5e-07 | 2.6e-07 | 1.4e-07 | |
| pathoAD | SNX3 | excitatory neurons (L4) | 0.04 8.8e-03 | 2.7e-05 | 4.3e-05 | 3.8e-05 | |
| pathoAD | SORL1 | excitatory neurons (L5/6) | -0.11 2.1e-02 | 7.5e-06 | 9.2e-06 | 1.2e-05 | |
| pathoAD | SPAG9 | astrocytes | 0.13 3.2e-02 | 2.2e-03 | 2.5e-03 | 1.2e-06 | |
| pathoAD | SPOCK3 | oligodendrocytes | 0.06 7.0e-03 | 1.1e-17 | 1.1e-17 | 4.9e-08 | |
| pathoAD | SPTBN1 | excitatory neurons (L2/3) | 0.06 9.8e-03 | 2.7e-10 | 3.8e-10 | 3.9e-06 | |
| pathoAD | SPTBN1 | excitatory neurons (L5/6) | 0.17 2.0e-02 | 7.8e-14 | 8.8e-14 | 2.4e-09 | |
| pathoAD | SRGAP2C | microglia | 0.2 3.9e-02 | 2.9e-05 | 3.1e-05 | 6.9e-06 | |
| pathoAD | ST6GAL1 | microglia | 0.24 2.3e-02 | 6.0e-23 | 6.1e-23 | 3.2e-06 | |
| pathoAD | SYNDIG1 | excitatory neurons (L5/6) | -0.13 3.6e-02 | 6.5e-03 | 9.8e-03 | 3.2e-05 | |
| pathoAD | SYNDIG1 | microglia | 0.15 3.1e-02 | 5.1e-05 | 5.3e-05 | 3.2e-06 | |
| pathoAD | SYT1 | excitatory neurons (L4) | 0.03 2.5e-03 | 9.3e-24 | 1.0e-23 | 8.3e-06 | |
| pathoAD | SYT1 | excitatory neurons (L5/6) | 0.07 7.4e-03 | 7.0e-18 | 7.3e-18 | 1.1e-10 | |
| pathoAD | SYT1 | inhibitory neurons (PV) | 0.05 7.6e-03 | 7.3e-11 | 7.7e-11 | 2.4e-07 | |
| pathoAD | TCF7L2 | astrocytes | -0.12 1.9e-02 | 7.5e-08 | 7.9e-08 | 1.2e-06 | |
| pathoAD | TCF7L2 | excitatory neurons (L2/3) | -0.17 2.6e-02 | 1.1e-08 | 2.3e-08 | 3.0e-07 | |
| pathoAD | TCF7L2 | excitatory neurons (L4) | -0.08 1.5e-02 | 1.4e-06 | 2.7e-06 | 1.9e-04 | |
| pathoAD | TENM2 | astrocytes | -0.23 1.9e-02 | 2.0e-27 | 0.0e+00 | 3.9e-06 | |
| pathoAD | TENM2 | excitatory neurons (L5/6) | 0.09 2.0e-02 | 1.6e-04 | 2.0e-04 | 2.5e-04 | |
| pathoAD | TENM2 | inhibitory neurons (PV) | 0.1 8.7e-03 | 1.2e-28 | 1.3e-28 | 3.6e-08 | |
| pathoAD | TLE4 | oligodendrocytes | 0.12 1.3e-02 | 3.5e-15 | 3.8e-15 | 1.8e-07 | |
| pathoAD | TLN2 | excitatory neurons (L4) | -0.03 8.1e-03 | 2.2e-04 | 3.6e-04 | 4.2e-04 | |
| pathoAD | TMBIM6 | excitatory neurons (L2/3) | 0.1 1.3e-02 | 4.2e-12 | 6.2e-12 | 1.4e-08 | |
| pathoAD | TMEM165 | excitatory neurons (L4) | -0.08 1.4e-02 | 1.6e-07 | 2.8e-07 | 1.2e-05 | |
| pathoAD | TMEM165 | inhibitory neurons (PV) | -0.14 3.6e-02 | 3.5e-03 | 5.0e-03 | 3.2e-05 | |
| pathoAD | TMEM165 | oligodendrocytes | -0.08 8.2e-03 | 5.1e-21 | 0.0e+00 | 1.4e-08 | |
| pathoAD | TMTC3 | excitatory neurons (L4) | 0.08 1.6e-02 | 7.0e-06 | 1.4e-05 | 5.3e-11 | |
| pathoAD | TRIM9 | astrocytes | 0.16 2.2e-02 | 1.9e-10 | 2.0e-10 | 1.4e-07 | |
| pathoAD | TRIM9 | inhibitory neurons (PV) | -0.12 1.7e-02 | 1.5e-10 | 1.7e-10 | 6.4e-08 | |
| pathoAD | TRPM3 | astrocytes | 0.09 1.4e-02 | 3.8e-10 | 3.9e-10 | 1.4e-06 | |
| pathoAD | TTC3 | excitatory neurons (L4) | 0.06 5.6e-03 | 2.0e-23 | 2.4e-23 | 4.8e-06 | |
| pathoAD | TTC3 | inhibitory neurons (PV) | 0.08 1.6e-02 | 3.3e-06 | 3.8e-06 | 5.8e-06 | |
| pathoAD | TTC3 | oligodendrocytes | 0.13 1.6e-02 | 2.8e-12 | 3.2e-12 | 5.3e-11 | |
| pathoAD | TUBA1B | inhibitory neurons (SST) | 0.15 2.8e-02 | 9.0e-05 | 9.5e-05 | 4.8e-06 | |
| pathoAD | UBE2E2 | microglia | 0.14 2.9e-02 | 6.3e-05 | 6.6e-05 | 2.7e-06 | |
| pathoAD | UBR2 | excitatory neurons (L5/6) | -0.12 2.6e-02 | 1.7e-04 | 2.2e-04 | 3.2e-06 | |
| pathoAD | UBR3 | excitatory neurons (L4) | -0.06 7.3e-03 | 3.7e-14 | 4.7e-14 | 5.1e-09 | |
| pathoAD | UBR3 | excitatory neurons (L5/6) | -0.07 2.2e-02 | 4.4e-03 | 5.8e-03 | 1.2e-05 | |
| pathoAD | UCHL1 | excitatory neurons (L2/3) | 0.08 8.7e-03 | 1.1e-19 | 1.4e-19 | 4.9e-08 | |
| pathoAD | UCHL1 | excitatory neurons (L4) | 0.04 5.0e-03 | 6.8e-12 | 8.3e-12 | 5.2e-05 | |
| pathoAD | UCHL1 | inhibitory neurons (PV) | 0.07 1.7e-02 | 3.8e-04 | 4.5e-04 | 1.7e-05 | |
| pathoAD | UNC5A | excitatory neurons (L4) | 0.1 1.3e-02 | 1.3e-13 | 1.9e-13 | 3.6e-08 | |
| pathoAD | XYLT1 | oligodendrocyte progenitor cells | -0.11 1.3e-02 | 6.2e-15 | 6.4e-15 | 8.3e-06 | |
| pathoAD | ZEB2 | oligodendrocyte progenitor cells | 0.09 2.3e-02 | 3.4e-03 | 3.9e-03 | 3.9e-06 | |
| pathoAD | ZFHX3 | microglia | 0.18 3.2e-02 | 3.3e-06 | 3.5e-06 | 1.6e-09 | |
| pathoAD | ZNF483 | excitatory neurons (L2/3) | 0.07 1.2e-02 | 9.8e-09 | 1.5e-08 | 8.5e-08 | |
| pathoAD | ZNF483 | excitatory neurons (L4) | 0.04 7.4e-03 | 5.9e-07 | 8.5e-07 | 3.7e-04 | |
| pathoAD | ZNF609 | microglia | 0.25 4.8e-02 | 5.0e-05 | 5.3e-05 | 1.1e-07 |